肾上腺髓质素对大鼠肠系膜微血管和微淋巴管的作用

应用活体显微电视录象技术，观察上腺髓质素对大鼠肠系膜微血管微淋巴管的作用及其对去甲肾上腺素，内皮素作用的是结果表明，ＡＤＭ直接扩张肠系膜各级微血管和向一淋巴管，拮抗ＮＥ和ＥＴ引起的微血效及微循环血流液态的异常改变。ＡＤＭ的上述作用可被一氧化氮生成抑制剂Ｎ＾９－ｎｉｔｒｏ－Ｌ－ａｒｇｉｎｉｎｅ（Ｌ－ＮＮＡ）显著抑制。

EFFECT OF ADRENOMEDULLIN ON MESENTERIC MICROVESSELS AND MICROLYMPHATICS IN RAT

The dilatant effect of adrenomedullin (ADM), a novel peptide of 52 aminoacids, on the mesenteric microvessels and microlymphatics was investigated under microscopic observation. 10-6 mol/ L ADM could also ameliorate alteration of thehemorheology induced by 10-5 mol/L norepinephrine (NE) or 10-7 mol/L endothelin(ET). However, this ameliorative response was markedly inhibited in the presence ofNG-nitro-L-arginine (L-NNA), an inhibitor for production of nitric oxide