| 中枢应用β-内啡肽对大鼠血浆唾液酸水平的影响以及与免疫功能的关系 |
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| 作者姓名： | Chen WF Chen L Lu XW Chen JJ |
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| 作者单位： | 1. 青岛大学医学院生理教研室
2. 青岛大学医学院附属医院检验科,青岛,266021 |
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| 摘 要： | 实验选择体重２００－２５０ｇ健康Ｗｉｓｔａｒ大鼠６４只，采用麻醉大鼠中枢微量注射，分光光测定法及免疫组织化学法，研究侧脑室，弓状核（ＡＲＣ）区注射β－内啡肽（β－ＥＰ）对大鼠血浆唾液酸（ＳＡ）水平的影响及与免疫功能的关系，结果表明：（１）侧脑室注射β－ＥＰ可明显降低血浆ＳＡ水平；（２）血浆ＳＡ水平在ＡＲＣ区注射β－ＥＰ后明显降低，此效应可被Ｍ胆碱受体阻断剂阿托品或切断双侧颈迷走神经所阻断；（３）Ａ
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| 关 键 词： | 神经中枢 血浆 唾液酸 β－内啡肽 免疫功能 |
Effect of beta-endorphin on plasma sialic acid level in rats and the relationship with the immune function |
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| Chen WF,Chen L,Lu XW,Chen JJ.Effect of beta-endorphin on plasma sialic acid level in rats and the relationship with the immune function[J].Acta Physiologica Sinica,1999,51(3):253-257. |
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| Authors: | Chen W F Chen L Lu X W Chen J J |
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| Institution: | Department of Physiology, The Medical College of Qingdao University, Qingdao 266021. |
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| Abstract: | With the use of beta-EP microinjection into the central nervous system, spectrophotometrical analysis and immunochemical method we studied the effect of beta-Endorphin (beta-EP) on plasma sialic acid (SA) level. The results indicate: (1) The plasma SA level was significantly decreased after microinjection of beta-EP into the lateral ventricle (LV); (2) When beta-EP was microinjection into nucleus arcuatus (ARC), the plasma SA level was significantly decreased (P < 0.05). This effect can be blocked by i.v. atropine or vagotomy; (3) Microinjection of beta-EP into ARC can cause the increase of CD3, CD4 and CD4/CD8, while CD8 was decreased. The above results suggest that the possible mechanism underlying the decrease of plasma SA level is mediated by cholinergic muscarinic receptor, and the cellular immune function is enhanced. |
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