| 脑室注射ET－1拮抗剂BQ123和ET抗血清使主动脉狭窄──高盐型高血压大鼠血压下降 |
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| 引用本文： | 马晓飞,邱学才,唐朝枢.脑室注射ET－1拮抗剂BQ123和ET抗血清使主动脉狭窄──高盐型高血压大鼠血压下降[J].生理学报,1994(4). |
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| 作者姓名： | 马晓飞 邱学才 唐朝枢 |
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| 作者单位： | 北京医科大学生理学系，病理生理教研室 |
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| 摘 要： | 侧脑室注射ＥＴ－１受体阻断剂ＢＱ１２３可明显降低腹主动脉狭窄──高盐摄入型实验性高血压大鼠的血压，并呈剂量效应关系。大剂量的ＢＱ１２３还可以使该型高血压大鼠心率减慢。侧脑室注射血管内皮素抗血清也可使该型高血压大鼠血压下降。以上结果表明中枢内皮素在高血压发生的病理生理中可能起一定作用。另外ＥＴ－１的拮抗剂ＢＱ１２３与ＥＴ－抗血清的抗高血压作用可能具有一定的临床意义。
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| 关 键 词： | 高血压 内皮素 BQ123 ET抗血清 脑室注射 |
THE DEPRESSOR EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF BQ123 AND ENDOTHELIN (ET)-ANTISERUM ON HYPERTENSIVE RATS PRODUCED BY AORTA STENOSIS AND HYPERSALINE UPTAKE |
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| MA XIAO-FEI AND QIU XUE-CAI.THE DEPRESSOR EFFECT OF INTRACEREBROVENTRICULAR INJECTION OF BQ123 AND ENDOTHELIN (ET)-ANTISERUM ON HYPERTENSIVE RATS PRODUCED BY AORTA STENOSIS AND HYPERSALINE UPTAKE[J].Acta Physiologica Sinica,1994(4). |
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| Authors: | MA XIAO-FEI AND QIU XUE-CAI |
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| Abstract: | An experimental model of hypertensive rat was made by abdominal aorta stenosis and hypersaline uptake. The blood pressure was significantly decreased by intracerebroventricular injection(i. c. v.) of BQ123 a potent antagonist of ET-1 receptor,in a dose-dependent manner. Negative chronotropic effect on the heart was produced by high dose of BQ123, while the depressor effect was produced by i. c. v. ET-antiserum.These results indicate that endothelin in CNS may play an important role in the pathological physiology of hypertension. |
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| Keywords: | hypertension endothelin BQ123 endothelin-antiserum intracerebroventricular injection |
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