中央杏仁核,外侧下丘脑／穹窿周围区,室旁核均参与岛皮层升压反应

实验用乌拉坦麻醉、箭毒制动、人工呼吸的大鼠。将谷氨酸注入岛皮层（ＩＮＳ）以及将Ｐ物质（ＳＰ）注入外侧下丘脑／穹窿周围区（ＬＨ／ＰＦ）或室旁核均引起升压反应。ＩＮＳ－升压反应可被杏仁核（ＡＣ）内预先注射普鲁卡因或谷氨酸二乙酯（ＧＤＥＥ，谷氨酸拮抗剂）以及ＬＨ／ＰＦ内注射［Ｄ－Ｐｒｏ＾２，Ｄ－Ｐｈｅ＾７，Ｄ－Ｔｒｐ＾９］－ＳＰ（ＤＰＤＰＤＴ，ＳＰ拮抗剂）明显衰减，但ＬＨ／ＰＦ内ＧＤＥＥ预处理对该反应无

INVOLVEMENT OF NUCLEUS AMYGDALOIDEUS CENTRALIS,LATERAL HYPOTHALAMUS / PERIFORNICAL REGION AND NUCLEUS PARAVENTRICULARIS IN INSULAR CORTEX-PRESSOR RESPONSE

In urethane-anesthetized, tubocurarine-immobilized and artificially ventilated rats, glutamate (Glu) injection into the insular cortex (INS) and substance P injection into the lateral hypothalamus-perifornical region (LH/PF) or nucleus paraventricularis (NPV) caused pressor responses. Preinjection of procaine or glutumate diethyl ester (GDEE, a glutumate antagonist) bilaterally into the nucleus amygdaloideus centralis (AC) and D- Pro2, D- Phe7, D- Trp9] - substance P (DPDPDT, a substunce P antugonist), but not GDEE, into the LH/PF markedly attenuated the pressor response induced by glutamate injection into the INS. Procaine or DPDPDT preinjection into the NPV also reduced the INS-pressor response. Since the LH/PF and NPV were found to mediate the AC-pressor response, the above results suggest that the INS- pressor response is the final outcome of activation of AC (Glu-receptor) -LH/PF and NPV (SPreceptor) system.