| 侧脑室注射心房钠尿肽对大鼠室旁核单位放电的影响 |
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| 引用本文： | 祁金顺,张家驹,马丽云,杨旭东.侧脑室注射心房钠尿肽对大鼠室旁核单位放电的影响[J].生理学报,1991(4). |
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| 作者姓名： | 祁金顺 张家驹 马丽云 杨旭东 |
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| 作者单位： | 天津医学院生理学教研室，天津医学院生理学教研室，天津市内分泌研究所，天津医学院生理学教研室 天津300070，天津300070，天津300070 |
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| 摘 要： | 本实验利用微电极技术在大鼠下丘脑共记录到118个自发放电单位,其中84个位于室旁核(PVN)内,34个位于 PVN 邻近部位。侧脑室注入心房钠尿肽(ANP)后,受其影响的 PVN神经元和 PVN 邻近部位神经元,分别有91%(P<0.005)和71%(P>0.05)表现为自发放电频率减少;侧脑室注入高渗 NaCl 溶液则分别使64.7%(P<0.005)和61.1%(P>0.05)的神经元自发放电频率增加。结果表明,侧脑室注入 ANP 对 PVN 神经元自发放电活动具有明显的抑制作用。
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| 关 键 词： | 心房钠尿肽 高张盐水 室旁核 单位放电 |
EFFCT OF INTRACEREBROVENTRICULAR ADMINISTRATION OF ATRIAL NATRIURETIC POLYPEPTIDE ON UNIT DISCHARGES OF RAT PARAVENTRICULAR NUCLEUS |
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| QI JIN-SHUN,ZHANG JIA-JU,MA LI-YUN,YANG XU-DONG.EFFCT OF INTRACEREBROVENTRICULAR ADMINISTRATION OF ATRIAL NATRIURETIC POLYPEPTIDE ON UNIT DISCHARGES OF RAT PARAVENTRICULAR NUCLEUS[J].Acta Physiologica Sinica,1991(4). |
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| Authors: | QI JIN-SHUN ZHANG JIA-JU MA LI-YUN YANG XU-DONG |
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| Abstract: | We have applied microelectrode technique to record 118 spontaneously firingunits from the hypothalamus in rats.Detection of the recording sites showed that84 were in the paraventricular nucleus(PVN)and 34 were near the PVN(near-PVN).After intracerebroventricular(i.c.v.)administration of atrial natriureticpolypeptide(ANP),91%(P<0.005)of the PVN neurones and 71%(P>0.05)of near-PVN neurones sensitive to ANP showed a significant decrease in spontane-ously firing rate.After i.c.v.administration of hypertonic NaCl solution,64.7%(P<0.005)of the PVN neurones and 61.1%(P>0.05)of near-PVN neuronesshowed a significant increase in firing rate.The results indicate that i,c.v.administration of ANP profoundly inhibitsthe electrical activity of the PVN neurones,but hypertonic NaCl solution markedlystimulates the PVN neurones. |
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| Keywords: | atrial natriuretic polypeptide hypertonic saline PVN unit discharge |
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