| Na^＋,K^＋离子通道阻滞剂对离体大鼠黄体细胞... |
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| 引用本文： | 赵玉莲,王京华.Na^＋,K^＋离子通道阻滞剂对离体大鼠黄体细胞...[J].生理学报,1991,43(5):508-511. |
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| 作者姓名： | 赵玉莲 王京华 |
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| 摘 要： |
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| 关 键 词： | 黄体细胞 孕酮 离子通道 阻滞剂 |
Effect of K+, Na+ ionic channel blocker on progesterone production by rat corpus luteal cells] |
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| Y L Zhao,J H Wang,C P Cheng.Effect of K+, Na+ ionic channel blocker on progesterone production by rat corpus luteal cells][J].Acta Physiologica Sinica,1991,43(5):508-511. |
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| Authors: | Y L Zhao J H Wang C P Cheng |
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| Institution: | Department of Physiology, Harbin Medical University. |
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| Abstract: | Two ionic channel blockers, TEA and TTX, were used in the present investigation to test whether blocking of Na+, K+ ion channels would affect the production of progesterone by corpus luteum (CL) cells of rat. Both TEA (10(-3) mol/L) and TTX (10(-3) mol/L) increased progesterone production significantly after treatment. This effect of the blockers could be completely inhibited by tyrosine (Tyr). In addition, Tyr was capable of reversing the combined effect of TEA, TTX and hCG on progesterone secretion. It is suggested that the concentration gradient of Na+ and K+ across the CL cell membrane in experiments mentioned above is implicated in steroidogenesis. |
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