花生油及油酸对消炎痛引起的大鼠胃粘膜损伤的保护作用

本工作研究了花生油及油酸对由消炎痛所致的大鼠胃粘膜损伤的保护作用。用花生油1.0ml,油酸0.25、0.5和1.0ml 灌胃均能明显地减轻由消炎痛引起的胃粘膜损伤,其中油酸的作用还呈现明显的量-效关系。而30%甘油、油酸乙酯、5%葡萄糖或0.1%乙酸各1.0ml灌胃则无效。将油酸注入空肠,其作用与灌胃相似。阿托品、酚妥拉明和心得安不能阻断油酸的上述保护作用。这些结果表明,花生油及油酸具有明显的保护胃粘膜的作用。油酸这种作用主要不是通过提供能量,也不是通过副交感神经和交感神经传递,而可能是通过它作用于小肠刺激多种胃肠激素释放而产生的。

EFFECT OF PEANUT OIL AND OLEIC ACID ON INDOMTHACIN-INDUCED GASTRIC MUCOSAL DAMAGE IN RATS

The effect of peanut oil and oleic acid on indomethacin-induced gastric mucosa(?)damage in rats and the mechanism of action of oleic acid were studied.The resultswere as follows:(1)Peanut oil 1.0 ml and oleic acid in doses of 0.25,0.5 or 1.0 ml administeredorally inhibited significantly the development of gastric mucosal damage induced byindomethacin and the inhibitory action of oleic acid was dose-dependent.(2)30% glycerin,ethyl oleate,5% glucose or 0.1% acetic acid 1.0 ml admini-stered orally had no effect on the development of gastric mucosal damage induced byindomethacin.(3)The action of oleic acid introduced into jejunum directly was similar to thatadministered orally.(4)Atropine,phentolamine or propranolol had no effect on the cytoprotectionof peanut oil.From the above results it is suggested that peanut oil and oleic acid may exerta significant cytoprotective effect on the indomethacin-induced gastric mucosaldamage.The action of oleic acid was resulted neither from its energy supplyingaction nor via autonomic nerves,but might be related to the gut hormones whichwere released by the stimulation of oleic oil in the intestine.