| （－）SPD和（－）THP对蓝斑核去甲肾上腺素能神经元自发放电的影响 |
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| 引用本文： | 吴建华,金国章.（－）SPD和（－）THP对蓝斑核去甲肾上腺素能神经元自发放电的影响[J].生理学报,1995(6). |
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| 作者姓名： | 吴建华 金国章 |
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| 作者单位： | 中国科学院上海药物研究所 |
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| 摘 要： | 利用在体记录大鼠蓝斑核神经元单位放电，研究了（－）ＳＰＤ和（－）ＴＨＰ对其放电活动的影响。结果表明：（－）ＳＰＤ通过去甲肾上腺素α２受体，以剂量依赖方式增强蓝斑核神经元放电，但较大剂量却对神经元放电有一定抑制。然而（－）ＴＨＰ可使蓝斑核去甲肾上腺素能神经元出现可逆性放电抑制。
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| 关 键 词： | 蓝斑 单位放电 （－）千金藤啶碱 （－）四氢巴马汀 |
EFFECTS OF (-) SPD AND (-) THP ON THE FIRING OF NORADRENERGIC NEURONS IN LOCUS COERULEUS |
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| Wu JIAN HUA AND JIN GUO-ZHANG.EFFECTS OF (-) SPD AND (-) THP ON THE FIRING OF NORADRENERGIC NEURONS IN LOCUS COERULEUS[J].Acta Physiologica Sinica,1995(6). |
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| Authors: | Wu JIAN HUA AND JIN GUO-ZHANG |
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| Abstract: | The.effects of (-) SPD and (-) THP on the norodrenergic neurons in rat locus coeruleus were investigated by recording the in ho spontaneous firing.It was found that (-) SPD could increase the firing frequency of the NE neurons via antagonistic action on a2 autoreceptors in a dose- dependent manner, while a2 receptor agonist clonidine exerted an inhibitory effect. (-) THP induced inhibitory. firing of the neurons,however,irreversible. |
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| Keywords: | locus coeruleus unit firing (-) stepholidine (-) tetrahydropalmatine |
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