| 亮氨酸脑啡肽抑制培养大鼠主动脉平滑肌细胞增殖 |
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| 引用本文： | 李莹,林树新.亮氨酸脑啡肽抑制培养大鼠主动脉平滑肌细胞增殖[J].生理学报,1997,49(4):452-454. |
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| 作者姓名： | 李莹 林树新 |
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| 作者单位： | 第四军医大学基础部病理生理学教研室!西安，710032，第四军医大学基础部病理生理学教研室!西安，710032，第四军医大学基础部病理生理学教研室!西安，710032 |
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| 摘 要： | 实验以培养的ＳＤ大鼠胸主动脉平滑肌细胞为模型，用四唑盐比色地及＾３Ｈ－ＴｄＲ掺入技术动态观察发现亮氨酸脑啡肽可显著抑制血管平滑肌细胞的增殖及ＤＮＡ的合成，阿片受体阻断剂纳洛酮对ＶＳＭＣｓ的增殖及ＤＮＡ的合成无影响，但ＮＡＬ可拮抗亮氨酸脑啡肽对ＶＳＭＣｓ增殖的抑制作用。
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| 关 键 词： | 血管平滑肌细胞 亮氨酸脑啡肽 细胞增殖 |
INHIBITORY EFFECTS OF L-ENK ON THE PROLIFERATION OF CULTURED SMOOTH MUSCLE CELLS OF RATS |
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| LI YING,LIN SHU-XIN,WANG RUI.INHIBITORY EFFECTS OF L-ENK ON THE PROLIFERATION OF CULTURED SMOOTH MUSCLE CELLS OF RATS[J].Acta Physiologica Sinica,1997,49(4):452-454. |
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| Authors: | LI YING LIN SHU-XIN WANG RUI |
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| Abstract: | Using method of MTT and 3H-TdR incorporation, the effect of L-ENK on proliferation and DNA synthesis of the cultured thoracic aortic vascular smooth muscle cells(VSMCs) of SD rats was investigated. The results indicated that L-ENK (10-5~10-4mol/L) could markedly inhibit proliferation and DNA synthesis of VSMCs, while NAL(10-8~10-5 mol/L) had no such effect, but could antagonize the inhibitory action ofL-ENK on the proliferation of VSMCs. |
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| Keywords: | leucine-enkephalin (L-ENK) NAL (NAL) vascular smooth muscle cells (VSMCs) |
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