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前列腺素E_1对肺的细胞保护作用
引用本文:孙秀泓,李俊成.前列腺素E_1对肺的细胞保护作用[J].生理学报,1986,38(4):397-402.
作者姓名:孙秀泓  李俊成
作者单位:湖南医学院生理教研室 (孙秀泓),湖南医学院生理教研室(李俊成)
摘    要:本文观察到体外培养下,前列腺素E_1 可降低豚鼠巨噬细胞和嗜酸粒细胞对肺细胞的细胞毒作用,可抑制肺泡巨噬细胞的吞噬活性,并能降低标记肺细胞的自发~3H]释放量。前列腺素E_1 对炎症效应细胞的抑制作用和对肺细胞的保护作用有显著的剂量-效应关系。鉴于巨噬细胞在机体防御和炎症反应中的作用极为重要,而激活巨噬细胞可以释放前列腺素E_1,推论在肺部疾病发展过程中,由激活巨噬细胞释放前列腺素使局部浓度增高时,可以负反馈地调整效应细胞的活力,并对正常肺细胞产生细胞保护作用,以减轻炎症效应细胞对肺组织的伤害。

关 键 词:前列腺素    巨噬细胞  嗜酸粒细胞  细胞保护作用  细胞毒作用  吞噬作用

CYTOPROTECTION OF PROSTAGLANDIN E_1 ON LUNG PARENCHYMAL CELLS
SUN XIU-HONG,LI JUN-CHEN.CYTOPROTECTION OF PROSTAGLANDIN E_1 ON LUNG PARENCHYMAL CELLS[J].Acta Physiologica Sinica,1986,38(4):397-402.
Authors:SUN XIU-HONG  LI JUN-CHEN
Institution:SUN XIU-HONG,LI JUN-CHEN Department of Physiology,Hunan Medical College
Abstract:It was observed that exogenously added prostaglandin E_1(PGE_1) inhibitedthe cytotoxic effect of activated macrophages and eosinophils of guinea pig for lungparenchymal cells, and decreased the spontaneous ~3H] release of lung cells. Also,PGE_1 inhibited the phagocytic ability of alveolar macrophages of guinea pig.There are significant dose-response relationships for the inhibitory effect of PGE_1on inflammatory effector cells and the cytoprotective effect of PGE_1 on lung cells.Since macrophages play most important role in bodily defence and inflammatoryresponses, and the activated macrophages release high concentration of PGE, itis postulated that PGE could act locally in cytoprotection to lung cells and in nega-tive feedback inhibition to limit effector cell activities during inflammatory processin lung diseases.
Keywords:prostaglandin  lung  macrophage  eosinophil  cytoprotection  cytotoxicity  phagocytosis
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