| MG-132对缺氧、血清饥饿诱导的MSCs凋亡和旁分泌的影响 |
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| 作者姓名： | Li ZW Fu R Zhao YR Zhao C Li ZY |
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| 作者单位： | 山西大学生物技术研究所化学生物学与分子工程教育部重点实验室; |
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| 基金项目： | supported by the National Natural Science Foundation of China(No.31040018) |
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| 摘 要： | 本研究采用缺氧、血清饥饿(hypoxia and serum deprivation,H/SD)联合处理骨髓间充质干细胞(mesenchymal stem cells,MSCs),模拟MSCs移植的心脏缺血微环境,研究蛋白酶体抑制剂MG-132对H/SD诱导的MSCs凋亡和旁分泌的影响.采用Annexin V/PI流式...
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| 关 键 词： | MG-132 骨髓间充质干细胞 白介素-10 凋亡 旁分泌 |
MG-132 enhances MSCs survival and IL-10 secretion under hypoxia and serum deprivation condition |
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| Li ZW,Fu R,Zhao YR,Zhao C,Li ZY.MG-132 enhances MSCs survival and IL-10 secretion under hypoxia and serum deprivation condition[J].Acta Physiologica Sinica,2011,63(6):525-532. |
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| Authors: | Li Zong-Wei Fu Rong Zhao Ya-Rui Zhao Chao Li Zhuo-Yu |
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| Institution: | LI Zong-Wei,FU Rong,ZHAO Ya-Rui,ZHAO Chao,LI Zhuo-Yu Institute of Biotechnology,Key Laboratory of Chemical Biology and Molecular Engineering of National Ministry of Education,Shanxi University,Taiyuan 030006,China |
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| Abstract: | Bone marrow-derived mesenchymal stem cells (MSCs) have emerged as attractive candidates for cellular therapies for heart and other organ-system disorders.However,a major dilemma in stem cell therapy for ischemic heart diseases is the low survival of transplanted cells in the ischemic and peri-infarcted region.In this study,MSCs were treated by hypoxia and serum deprivation (H/SD) to mimic the ischemic microenvironment of infarcted hearts where MSCs were transplanted.The effects of proteasome inhibitor MG-13... |
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| Keywords: | MG-132 mesenchymal stem cell IL-10 apoptosis paracrine |
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