低氧对兔主动脉和肺动脉损伤差异的探讨

将兔置于模拟海拔５ｋｍ（ＰＯ２＝１０．８ｋＰａ）低氧舱内２４ｈ，观察和比较低氧对主动脉和肺动脉形态学损伤的差异，结果显示５ｋｍ低氧２４ｈ，兔主动脉和肺动脉出现内膜下水肿，空泡增加，胞内线粒体和内质网不同程度损伤。但低氧对肺动脉的损伤明显重于主动脉，甚至已殃及平滑肌细胞。扫描电镜观察也显示模拟海拔５ｋｍ低氧２４ｈ，肺动脉内皮细胞出现损伤脱落，甚至出现断裂带，而在主动脉仅见内皮细胞轻微损伤。另又将离体

DIFFERENCES BETWEEN EFFECTS 0F HYP0XIA 0N RABBIT A0RTA AND PULMONARY ARTERY

The difference of morphological injury between rabbit aorta and pulmonny artery was compared after the animal was exposed to the altitude 5 km (P02 = 10. 8 kPa) for 24 h.Hypoxia caused subendothelial edema, increased vacuoles and injured mitochondria and endoplasmic reticulums in both kinds of endothelial cells. The impairment of pulmonary artery was obviously more severe than aorta and its smooth muscle cells were also affected. Forthermore, the exposure increased mitochondria in pulmonary artery endothelial cells. Bubbled with a mixture air of 95% N2-5% CO2 (Po2 = 4 kPa) led to an increase of pulmonary in tension, while hypoxia to the same extent induced aorta relaxation. These results indicate that hypoxia produces the differential effects on these two kinds of vessels, providing a possible explanation for the preduction of hypxic pulmonary hypertension.