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胍基丁胺对大鼠血流动力学的影响及其细胞机制
作者姓名:Li XT  He RR
作者单位:河北医科大学基础医学研究所生理室,石家庄,050017
摘    要:在麻醉大鼠研究静注胍基丁胺(AGM)对血流动力学的影响,并初步探讨其机制。结果如下:(1)静注AGM(10mg/kg)后,HR,MAP,LVP,±LVdp/dtmax,CI和TPRI均明显下降;(2)预先静注NOS抑制剂LNNA(15mg/kg)或腹腔内注射鸟苷酸环化酶抑制剂亚甲基蓝(50mg/kg),均不能阻断AGM的降压作用;(3)预先静注咪唑啉受体和α2肾上腺素能受体阻断剂idazoxan(2mg/kg)则可明显阻抑AGM的降压效应。以上结果表明,AGM对麻醉大鼠的降压机制,在于显著抑制心肌收缩性而使心输出量降低,以及舒张外周血管致使总外周阻力下降;此效应似主要由IR和/或α2AR所介导。

关 键 词:胍基丁胺  血流动力学  咪唑啉  受体  细胞机制

Hemodynamic effects of agmatine and its cellular mechanism in anesthetized rats
Li XT,He RR.Hemodynamic effects of agmatine and its cellular mechanism in anesthetized rats[J].Acta Physiologica Sinica,1999,0(2):229-233.
Authors:Li X T  He R R
Institution:Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017.
Abstract:The hemodynamic effects of intravenous injection of agmatine and their cellular mechanism were investigated in anesthetized rats. The results obtained are as follows. (1) Following intravenous injection of agmatine (10 mg/kg), HR, MAP, LVP, LV dp/dtmax, CI and TPRI were significantly decreased. (2) Pretreatment with NnitroLarginine (15 mg/kg) or methylene blue (50 mg/kg), did not affect the hypotensive effect of agmatine. (3) The hemodynamic effects induced by agmatine could be inhibited by prior intravenous injection of idazoxan (2 mg/kg), an 2adrenoceptor (2AR) and imidazoline receptor antagonist. The results indicate that the hypotensive effect induced by iv agmatine may be attributed to the decrease in cardiac output resulting from depression of myocardial contractility, as well as to the reduction in total peripheral resistance resulting from vasodilatation. These effects of agmatine may be mediated by imidazoline receptor and/or 2AR.
Keywords:agmatine  hemodynamics  imidazoline receptor  2adrenoceptor  
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