| 刺激中缝背核对视交叉上核光敏神经元单位放电的影响 |
| |
| 引用本文： | 俞光弟,邓柏澧.刺激中缝背核对视交叉上核光敏神经元单位放电的影响[J].生理学报,1997,49(3):314-320. |
| |
| 作者姓名： | 俞光弟 邓柏澧 |
| |
| 作者单位： | [1]苏州医学院神经生物学研究室 [2]香港理工大学应用生物化学科技系 |
| |
| 基金项目： | 国家自然科学基金!39470240 |
| |
| 摘 要： | 本实验观察刺激中缝背核对大鼠视交叉上核光敏神经元单位放电的影响，并进行药理学分析。结果表明，刺激ＤＲ能明显抑制ＳＣＮ神经元光诱发放电，这种抑制作用能被单胺氧化酶抑制剂优降宁增强，能被５－ＨＴ合成抑制剂对氯苯丙氨酸减弱，还能被５－ＨＴ受体拮抗剂赛庚啶阻断。结果提示，５－ＨＴ参与了刺激ＤＲ对ＳＣＮ光敏神经元放电的抑制。
|
| 关 键 词： | 丘脑 视交叉上核 中缝背核 光敏神经元 单位放电 |
EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARGES OF LIGHT-SENSITVE NEURONS OF SUPRACHIASMATIC NUCLEUS IN RATS |
| |
| YU GUANG-DI,WEI XIAO-PING, ZHANG HUI-QIN,XU SHUANG, YIN QI-ZHANG.EFFECT OF DORSAL RAPHE NUCLEUS STIMULATION ON UNIT DISCHARGES OF LIGHT-SENSITVE NEURONS OF SUPRACHIASMATIC NUCLEUS IN RATS[J].Acta Physiologica Sinica,1997,49(3):314-320. |
| |
| Authors: | YU GUANG-DI WEI XIAO-PING ZHANG HUI-QIN XU SHUANG YIN QI-ZHANG |
| |
| Abstract: | The effect of dorsal raphe nucleus (DR) stimulation on the unit discharge ofsuprachiasmatic nucleus (SCN) neurons was studied and analyzed pharmacologically inthe Wisher rats. Experimental results showed that DR stimulation could significantly inhibit the light-induced discharge of SCN neurons. Pharmacologically, this inhibitioncould be enhanced by monoamine oxidase inhibitor pargyline, attenuated by 5-hydroxytryptamine (5-HT) synthesis inhibitor parachlorphenylalanine and block by 5-HTrecepor antagonist cyproheptadine. It was suggested that the inhibitory effect of DRstimulation on the light-sensitive SCN neuron discharge might be mediated by 5-HT. |
| |
| Keywords: | suprachiasmatic nucleus dorsal raphe nucleusl light-snsitive neuron pargyline cyproheptadine Parachlorophenylalanine |
| 本文献已被 CNKI 维普 等数据库收录！ |
