| 藏羚羊和藏系绵羊血液内分泌激素水平的比较研究 |
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| 作者姓名： | Zhang XF Yang YZ Pei ZW Wang SY Chang R Ge RL |
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| 作者单位： | 青海省格尔木市人民医院高原病科;青海大学高原医学研究中心; |
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| 基金项目： | supported by National Basic Research Development Program of China(973Program,No.2006CB504100) |
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| 摘 要： | 为了探讨藏羚羊适应高原环境的内分泌系统的功能特点,我们对藏羚羊(9只)和藏系绵羊(10只)进行了内分泌激素水平的比较。在海拔4300m地区捕获到动物后,随即运至海拔2800m实验基地,次日早晨抽取右侧颈静脉血,采用放射免疫法(radioimmunoassay,RIA)或酶联免疫吸附实验法(enzyme-linked immunosorbent assay,ELISA)测定下丘脑-腺垂体-外周腺轴20项内分泌激素水平,用导管插入术记录动物心率(heart rate,HR)、收缩压(systolic blood pressure,SBP)、舒张压(diastolic bloodpressure,DBP)和平均肺动脉压(mean pulmonary arterial pressure,mPAP)。使用血细胞分析仪测定血红蛋白(hemoglobin,Hb)含量。结果显示,藏羚羊血液中FT3、FT4、AngⅡ水平显著低于藏系绵羊,而藏羚羊血液中TRH、CRH、F、GHRH、E2、Ald、ACTH、CGRP水平则显著高于藏系绵羊。相对于藏系绵羊,藏羚羊HR、mPAP、SBP、DBP和Hb含量明显较低。藏羚羊和藏系绵羊的H...
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| 关 键 词： | 藏羚羊 藏系绵羊 高原低氧适应 内分泌激素 |
Comparisons of endocrine hormones levels between Tibetan antelope and Tibetan sheep |
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| Zhang XF,Yang YZ,Pei ZW,Wang SY,Chang R,Ge RL.Comparisons of endocrine hormones levels between Tibetan antelope and Tibetan sheep[J].Acta Physiologica Sinica,2011,63(4):342-346. |
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| Authors: | Zhang Xue-Feng Yang Ying-Zhong Pei Zhi-Wei Wang Sheng-Yu Chang Rong Ge Ri-Li |
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| Institution: | Department of High Altitude Disease, People's Hospital of Golmud, Golmud 816000, China. |
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| Abstract: | The Tibetan antelope, a prototype mammal, has developed a unique adaptation to extreme high altitude-associated hypoxia. To investigate the role of the endocrine system in adaptation to high altitude in the Tibetan antelope, comparisons of endocrine hormones levels between Tibetan antelope (n = 9) and Tibetan sheep (n = 10) were performed. Both two kinds of animals were captured at an altitude of 4 300 m and then transported to experimental base at 2 800 m altitude. The blood samples were drawn from right e... |
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| Keywords: | Tibetan antelope Tibetan sheep high altitude hypoxia adaptation endocrine hormone |
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