| 乙醇对胃粘膜的损伤及牛磺酸的保护作用 |
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| 作者姓名： | Xie Y Li XP Wang CW Huang DQ Zhu JQ Zhang KH Chen J |
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| 作者单位： | 江西医学院第一附属医院消化研究所,南昌,330006 |
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| 摘 要： | 为了探讨乙醇性胃粘膜损伤和牛磺酸对其保护作用的机制，将４０只ＳＤ大鼠分为对照组、乙醇损伤组和牛磺酸保护组，观察其胃粘膜中内皮素（ＥＴ）、一氧化氮合成酶（ＮＯＳ）、生长抑素（ＳＳ）和血管活性肠肽（ＶＩＰ）的变化。结果如下：（１）随着乙醇作用时间延长、粘膜的损伤加重，胃粘膜内ＥＴ含量显著上升，而ＮＯＳ、ＳＳ和ＶＩＰ含量显著下降；（２）牛磺酸可显著减轻乙醇性胃粘膜损伤，抑制ＥＴ释放，增加ＮＯＳ活性和ＳＳ、ＶＩＰ的含量。上述结果表示，ＥＴ、ＮＯＳ、ＳＳ和ＶＩＰ的变化参与了乙醇性胃粘膜损伤的病理生理过程；牛磺酸对乙醇性胃粘膜损伤具有保护作用，可能与其调节胃粘膜内ＥＴ、ＮＯＳ、ＳＳ和ＶＩＰ的释放与活性有关。
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| 关 键 词： | 乙醇 胃粘膜损伤 牛磺酸 内皮素 一氧化氮合成酶 |
Ethanol-induced gastric mucosal injury and the protection of taurine against the injury in rats |
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| Xie Y,Li XP,Wang CW,Huang DQ,Zhu JQ,Zhang KH,Chen J.Ethanol-induced gastric mucosal injury and the protection of taurine against the injury in rats[J].Acta Physiologica Sinica,1999,51(3):310-314. |
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| Authors: | Xie Y Li X P Wang C W Huang D Q Zhu J Q Zhang K H Chen J |
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| Institution: | First Affiliated Hospital of Jiangxi Medical College, Nanchang 330006. |
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| Abstract: | SD rats were randomly divided into control group, ethanol induced injury group and taurine protective group for the measurement of the contents of endothelin (ET), nitric oxide synthetase (NOS), somatostatin (SS) and vasoactive intestinal peptide (VIP). The results are as follows. The gastric mucosa was damaged by 75% ethanol, being aggravated with prolonged application time, as shown by a significant increase of the ET content and decreases of the contents of NOS, VIP and SS in the gastric mucosa. In the taurine group, decrease of ET content and increase of the contents of NOS, SS and VIP in the gastric mucosa were observed. Apparently, the changes in ET, NOS, SS and VIP contents of gastric mucosa serve as reliable indices in the pathogenesis by ethanol and protective effect by taurine. |
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| Keywords: | ethanol gastric mucosal injury taurine endothelin nitric oxide synthetase |
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