刺激家兔肾内感受器和肾传入神经的血流动力学效应

在39只麻醉家兔观察刺激肾脏机械和化学感受器以及电刺激肾传入神经的血流动力学效应。增加输尿管压8—22mmHg 及经输尿管向肾盂内逆向灌注 NaCl(1.0 mol/L)及 KCl(0.15mol/L)溶液时,引起平均动脉压(MAP)和心率(HR)下降;切断双侧缓冲神经后,MAP 降低更为显著。电刺激肾传入神经时,HR 减慢,MAP、肠系膜动脉和后肢动脉灌流压降低,左心室收缩压及其微分值下降,心输出量(CO)和总外周阻力(TPR)减小;切断双侧窦神经和减压神经后,除 HK、CO 和 TPR 外,其余各血流动力学指标的减弱更为显著。由此提示,动脉压力感受器反射对肾传入神经激活的心血管效应有缓冲作用。

HEMODYNAMIC EPFECTS OF RENAL INTERORECEPTOR AND AFFERENT NERVE STIMULATION IN RABBIT

Hemodynamic effects of renal mechano- and chemoreceptor activation and afferent renal nerve stimulation were observed in 39 anesthetized rabbits. The mean arterial pressure (MAP) and heart rate (HR) were decreased following elevation of ureteral pressure (13-22 mmHg), and retrograde perfusion of NaCl (1.0 mol/L) or KCl (0.15 mol/L) into pelvis via ureter route. The decrease in MAP was enhanced by sinoaortic denervation. HR, MAP, mesentery arterial perfusion pressure (MPP), hindlimb arterial perfusion pressure (HLPP), left ventricular pressure (LVP), left ventricular dp/dtmax (LV dp/dtmax), cardiac output (CO) and total peripheral resistance (TPR) were decreased during electrical stimulation of afferent renal nerve. By sinoaortic denervation, the aforementioned hemodynamic parameters, except HR, CO and TPR, were reduced more markedly by electric stimulation of afferent renal nerves. Therefore it appears that sinoaortic depressor reflex plays a buffer role in the cardiovascular responses to the stimulation of afferent renal nerves.