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半夏蛋白的抗兔胚泡着床作用
引用本文:陈蕙玲,宋锦芬,陶宗晋.半夏蛋白的抗兔胚泡着床作用[J].生理学报,1984(4).
作者姓名:陈蕙玲  宋锦芬  陶宗晋
作者单位:中国科学院上海生理研究所 (陈蕙玲,宋锦芬),上海生物化学研究所(陶宗晋)
摘    要:半夏蛋白有很强的抗兔胚泡着床作用,子宫内注射500μg,抗着床率达100%。经半夏蛋白作用后的子宫内膜能使被移植的正常胚泡不着床。在子宫内经半夏蛋白孵育的胚泡移植到同步的假孕子宫,着床率随孵育时间延长而降低。用辣根过氧化物酶标记半夏蛋白的定位实验表明该蛋白结合在子宫内膜腺管的上皮细胞膜上。已知半夏蛋白有类似凝集素的活性,能与甘露聚糖结合,它的抗着床作用可能是由于该蛋白结合了母体和(或)子体细胞膜上的某些糖结构,改变了细胞膜的生物学行为所致。

关 键 词:着床  半夏蛋白  子宫内膜  胚泡

ANTI-IMPLANTATION EFFECT OF PINELLIN IN RABBITS
CHEN HUI-LING,SONG JIN-FEN,TAO ZONG-JIN.ANTI-IMPLANTATION EFFECT OF PINELLIN IN RABBITS[J].Acta Physiologica Sinica,1984(4).
Authors:CHEN HUI-LING  SONG JIN-FEN  TAO ZONG-JIN
Abstract:Pinellin,a protein isolated from the Chinese herb medicine plant Pinellia ter-nata,is shown to have a strong anti-implantation activity in rabbits.Studied bythe method of blastocyst transfer,it is shown that pinellin primarily affects the nor-mal function of the uterine endometrium.By using the technique of HRPase,themembranous surface of the glandular epithelium in the endometrium is found to bethe binding site of pinellin.The results mentioned above suggest that the anti-imp-lantation effect of pinellin may be due to its interference on the normal interactionbetween the endometrial and the embryonic cell.
Keywords:implantation  pinellin  uterine endometrium  blastocyst
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