| 钙离子对小鼠电针镇痛和吗啡镇痛影响的相似性 |
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| 引用本文： | 张祖暄,童静波,葛鸣,陈荣三.钙离子对小鼠电针镇痛和吗啡镇痛影响的相似性[J].生理学报,1983(2). |
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| 作者姓名： | 张祖暄 童静波 葛鸣 陈荣三 |
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| 作者单位： | 南京大学生物系
(张祖暄，童静波)，南京大学配位化学研究所
(葛鸣)，南京大学配位化学研究所(陈荣三) |
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| 摘 要： | 本工作以小鼠为对象研究了脑 Ca~(2 )水平与吗啡及电针镇痛的相互关系。脑室内注射杆菌肽和亮-脑啡肽能增强电针镇痛,后者可被腹腔注射 Ca~(2 )对抗。用多巴胺受体激动剂阿朴吗啡和拮抗剂氟派啶预处理并不改变 Ca~(2 )对电针镇痛的对抗作用,这表示脑内多巴胺类似不直接参与 Ca~(2 )对抗电针镇痛的作用。Ca~(2 )对抗电针镇痛和吗啡镇痛的时程十分相似。所有的结果表明,吗啡镇痛与电针镇痛的机理很可能是相同的。
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| 关 键 词： | 电针镇痛 吗啡 脑钙 阿朴吗啡 氟派啶 |
THE SIMILARITY OF INFLUENCES OF CALCIUM ON ELECTRO-ACUPUNCTURE ANALGESIA AND MORPHINE ANALGESIA |
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| ZHANG ZU-XUAN,TONG JING-BO AND GE MING.THE SIMILARITY OF INFLUENCES OF CALCIUM ON ELECTRO-ACUPUNCTURE ANALGESIA AND MORPHINE ANALGESIA[J].Acta Physiologica Sinica,1983(2). |
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| Authors: | ZHANG ZU-XUAN TONG JING-BO AND GE MING |
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| Abstract: | The correlation of Ca~(2 )level in the brain with analgesic effects of morphineas well as electric acupuncture in mice Was studied.The main results are asfollows.Intraventricular injection of bacitracin and L-enkephalin greatly enhan-ced electro-acupuncture analgesia in mice,and the effect was antagonized byintraperitoneal injection of Ca~(2 ).The antagonistic effect of Ca~(2 )was not alteredby pretreatment with apomorphine or droperidol,respectively a dopamine re-ceptor agonist and antagonist.This indicates that dopamine was not involvedin the action of Ca~(2 ).It is observed that antagonism induced by Ca~(2 )of mor-phine and that of electric acupuncture analgesia have a similar time course.All these observations indicate that the mechanism underlying the productionof morphine analgesia and electric acupuncture analgesia is probably the same. |
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| Keywords: | electro-acupuncture morphine brain calcium apomorphine droperidol |
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