Sensitivity of firing rate to input fluctuations depends on time scale separation between fast and slow variables in single neurons |
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Authors: | Brian Nils Lundstrom Michael Famulare Larry B Sorensen William J Spain Adrienne L Fairhall |
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Institution: | (1) Department of Physiology and Biophysics, University of Washington, Seattle, WA 98195, USA;(2) Department of Physics, University of Washington, Seattle, WA 98195, USA;(3) Neurology Section, Veterans Affairs Puget Sound Health Care System, 1660 South Columbian Way, Seattle, WA 98108, USA |
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Abstract: | Neuronal responses are often characterized by the firing rate as a function of the stimulus mean, or the f–I curve. We introduce a novel classification of neurons into Types A, B−, and B+ according to how f–I curves are modulated by input fluctuations. In Type A neurons, the f–I curves display little sensitivity to input fluctuations when the mean current is large. In contrast, Type B neurons display
sensitivity to fluctuations throughout the entire range of input means. Type B− neurons do not fire repetitively for any constant
input, whereas Type B+ neurons do. We show that Type B+ behavior results from a separation of time scales between a slow and
fast variable. A voltage-dependent time constant for the recovery variable can facilitate sensitivity to input fluctuations.
Type B+ firing rates can be approximated using a simple “energy barrier” model. |
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