Interaction of tetrasubstituted cationic aluminum phthalocyanine with artificial and natural membranes |
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| Authors: | A A Pashkovskaya I V Perevoshchikova V E Maizlish G P Shaposhnikov E A Kotova Yu N Antonenko |
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| Institution: | 1.Belozersky Institute of Physico-Chemical Biology,Lomonosov Moscow State University,Moscow,Russia;2.Ivanovo State University of Chemistry and Technology,Ivanovo,Russia |
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| Abstract: | A study of the properties of water-soluble tetrasubstituted cationic aluminum phthalocyanine (AlPcN4) revealed efficient binding of this photosensitizer to phospholipid membranes as compared with tetrasulfonated aluminum and
zinc phthalocyanine complexes. This also manifested itself in enhanced photodynamic activity of AlPcN4 as measured by the photosensitized damage of gramicidin channels in a planar bilayer lipid membrane. The largest difference
in the photodynamic activity of cationic and anionic phthalocyanines was observed in a membrane containing negatively charged
lipids, thereby pointing to significant contribution of electrostatic interactions to the binding of photosensitizers to a
membrane. Fluoride anions suppressed the photodynamic activity and binding to membrane of both tetraanionic and tetracationic
aluminum phthalocyanines, which supports our hypothesis that interaction of charged metallophthalocyanines with phospholipid
membranes is mostly determined by coordination of the central metal atom with the phosphate group of lipid. |
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