Exposing the Complex III Qo semiquinone radical |
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| Authors: | Haibo Zhang P Leslie Dutton |
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| Institution: | Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA |
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| Abstract: | Complex III Qo site semiquinone has been assigned pivotal roles in productive energy-conversion and destructive superoxide generation. After a 30-year search, a genetic heme bH knockout arrests this transient semiquinone EPR radical, revealing the natural engineering balance pitting energy-conserving, short-circuit minimizing, split electron transfer and catalytic speed against damaging oxygen reduction. |
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| Keywords: | Complex III Cytochrome bc1 Semiquinone Qo Superoxide Electron transfer |
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