Thymic antigen-reactive cells do not specify serological properties of antibody |
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Authors: | F R Orsini G Cudkowicz |
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Institution: | Department of Pathology, School of Medicine, State University of New York at Buffalo, Buffalo, New York 14214 U.S.A. |
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Abstract: | Irradiated mice of the (C3H × C57BL/10)F1 and (C57BL/6 × DBA/2)F1 strains were reconstituted with an excess of syngeneic bone marrow cells containing precursors of immunocytes, and with graded limiting numbers of thymocytes containing antigen-reactive cells (ARC), and then injected with sheep erythrocytes. The number of ARC and their possible specialization for serological properties of antibody were investigated by determining the titer of 2-mercaptoethanol-sensitive serum hemagglutinins and hemolysins 11 days after grafting. The limiting dilution assays indicated that the number of detectable ARC/106 thymocytes was of the same order of magnitude for both antibody responses. Agglutinins and lysins were associated in most recipient mice receiving an average of 1 ARC. Hence, serological properties of antibodies were not dictated by ARC, but by other cells participating in the immune responses, presumably of nonthymic origin. |
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