Activation and mechanism of action of suppressor macrophages |
| |
Authors: | A Lichtenstein R Murahata M Terpenning J Cantrell J Zighelboim |
| |
Institution: | 1. Division of Hematology/Oncology, Department of Medicine, Wadsworth Veteran''s Administration Medical Center, Los Angeles, California 90073 U.S.A.;2. Department of Microbiology and Immunology and Division of Hematology/Oncology, Department of Medicine, University of California Center for the Health Sciences, University of California School of Medicine, Los Angeles, California 90024 U.S.A.;3. Rocky Mountain Laboratories, NIAID, Hamilton, Montana, 59840 U.S.A. |
| |
Abstract: | Intravenous administration of Corynebacterium parvum to alloimmunized mice activates splenic suppressor macrophages that effectively curtail primary and secondary generation of cytotoxic T lymphocytes (CTLs) in vitro. CTL generation was significantly inhibited in suppressed primary cultures by Day 3, the earliest time point that activity is first detected in control cultures. Suppressor macrophages had to be present during the first 24–48 hr of culture to effectively curtail the generation of CTLs. However, if suppressor macrophages were reactivated by 48-hr in vitro culture and then added to primary sensitizations that had been initiated 48 hr previously, they were capable of significant suppression. Suppressor cells produced a soluble factor that mediated the inhibition of CTL generation. The production or action of this factor could not be counteracted by indomethacin. |
| |
Keywords: | To whom requests for reprints should be sent at: Department of Microbiology and Immunology University of California School of Medicine Los Angeles Calif 90024 |
本文献已被 ScienceDirect 等数据库收录! |
|