Evidence that immune RNA is messenger RNA. |
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| Authors: | P Bilello M Fishman G Koch |
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| Institution: | 1. Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA;2. Biology Department, New York University, New York, New York, USA;3. St. Jude Children''s Research Hospital, Memphis, Tennessee 38101 USA |
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| Abstract: | Exposure of rabbit spleen cell cultures to i-RNA isolated from T2 phage-exposed rabbit peritoneal exudate cells induces the synthesis of antigen and allotype specific 19S proteins even in the presence of actinomycin D. The same i-RNA directs the synthesis of proteins with comparable properties in cell-free extracts prepared from mouse L cells, indicating that i-RNA functions as mRNA and contains the information required to code for the synthesis of IgM antibodies. |
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