Chemical separation of helper cell function and delayed hypersensitivity responses |
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Authors: | Robert E Faith Michael I Luster John A Moore |
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Institution: | National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709 USA |
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Abstract: | Studies were performed to investigate the effects of the immunosuppressive chemical TCDD. Fetal and neonatal rats were exposed to TCDD through maternal dosing (5 μg/Kg) at Day 18 of gestation and on Days 0, 7, and 14 of postnatal life. Another group of neonatal rats were exposed to TCDD through maternal dosing on Days 0, 7, and 14 of postnatal life only. Parameters of cell-mediated and humoral immune function were investgiated. TCDD suppressed delayed hypersensitivity responses and responses to the mitogens Con A and PHA without affecting humoral immune function. Suppression of T-cell function was selective in that helper function was not suppressed. Transfer of primed T-lymphocytes from TCDD treated and non-treated animals into neonatally thymectomized animals confirmed this. Results indicate that delayed hypersensitivity function and helper function reside in distinct T-cell subsets. |
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Keywords: | Requests for reprints should be sent to: Robert E Faith Biomedical Research Center Oral Roberts University 7777 South Lewis Tulsa Oklahoma 74171 |
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