Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.) |
| |
Authors: | Zaghloul Ahmed M Gohar Ahmed A Naiem Zein Al-abdin M Abdel Bar Fatma M |
| |
Institution: | Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. |
| |
Abstract: | 8-beta-Hydroxypimar-15-en-19-oic acid (1), taxodione (2), 6,7-dehydro-8-hydrotaxodone (3), quercetin-3-O-beta-D-glucopyranoside (4), and shikimic acid (5) were isolated from the leaves of Taxodium distichum L. (Rich.) for the first time. Previously reported compounds beta-sitosterol (6), isorhamnetin (7), quercetin (8), isorhamnetin-3-O-alpha-arabinofuranoside (9), quercetin-3-O-a-arabinofuranoside (10)] have also been isolated. The activity of taxodione as an inhibitor for hepatic stellate cells was determined. The antitumour activity of 2, 3, and 5 using a DNA affinity probe was examined. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|