Self-regulatory role of 4-hydroxynonenal in signaling for stress-induced programmed cell death |
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Authors: | Awasthi Yogesh C Sharma Rajendra Sharma Abha Yadav Sushma Singhal Sharad S Chaudhary Pankaj Awasthi Sanjay |
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Institution: | Department of Molecular Biology and Immunology, University of North Texas Health Science Center, Fort Worth, TX 76107-2699, USA. yawasthi@hsc.unt.edu |
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Abstract: | Within the last two decades, 4-hydroxynonenal has emerged as an important second messenger involved in the regulation of various cellular processes. Our recent studies suggest that HNE can induce apoptosis in various cells through the death receptor Fas (CD95)-mediated extrinsic pathway as well as through the p53-dependent intrinsic pathway. Interestingly, through its interaction with the nuclear protein Daxx, HNE can self-limit its apoptotic role by translocating Daxx to cytoplasm where it binds to Fas and inhibits Fas-mediated apoptosis. In this paper, after briefly describing recent studies on various biological activities of HNE, based on its interactions with Fas, Daxx, and p53, we speculate on possible mechanisms through which HNE may affect a multitude of cellular processes and draw a parallel between signaling roles of H(2)O(2) and HNE. |
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Keywords: | 4-Hydroxynonenal Apoptosis Cell cycle signalling Fas P53 Heat shock factor 1 Daxx |
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