拉萨地区血浆同型半胱氨酸水平与脑梗死的相关性研究

目的：探讨在高原缺氧环境下，研究血浆同型半胱氨酸水平与脑梗死的相关性及临床意义，为高原地区脑梗死的防治提供依据。方法：随机选取西藏自治区人民医院2011年04月-2012年12月入院治疗的急性脑梗死患者166例作为观察组，选择同期就诊的150例健康检查者作为对照组，患者就诊第二日清晨采空腹静脉血送检。血浆同型半胱氨酸水平应用循环酶法测定，分析同型半胱氨酸水平与脑梗死的相关性。结果：观察组患者血浆中同型半胱氨酸水平明显高于对照组，差异显著具有统计学意义（P〈0．01）。结论：高原环境下，高同型半胱氨酸血症是脑梗死的独立危险因素，血浆同型半胱氨酸水平可作为脑血管疾病一级预防的常规检查指标，以及对缺血性脑卒中的指导治疗有重要意义。

Relationship between the Homocysteine Level and Cerebral Infarction in the Lhasa Area

Objective： To study the relationship and clinical significance between the homocysteine （Hcy） level and cerebral infarc- tion and to tmderstand the plateau hypoxia environment so as to provide the evidence for the prevention of cerebral infarction in plateau area. Methods： 166 patients with acute cerebral i nfarcti on who were treated in our hospital from April 2011 to December 2012 were selected to be the observation group, and another 150 healthy people who were taken the examination were chosen as the control group. Then the venous blood samples in the second morning and application Circle enzyme were measured by plasma homocysteine level. The relative factors of the homocysteine （Hcy） level and cerebral infarction were analyzed by SPSS19.0. Results： The homocysteine level of patients in the observation group was obviously higher than that of the control group with statistically significant difference （P〈0.01）. Conclusion： It i s indicated that the plateau hypoxia environment, high homocysteine levels could be the independent risk factors of cerebral infarction. Plasma homocysteine levels can be used as a routine examination indicator of the primary prevention on cerebrovascular disease,and take important significance to guide the treatment of cerebral infarction.