首页 | 本学科首页   官方微博 | 高级检索  
   检索      

重组人生长激素治疗生长激素缺乏症的疗效观察
引用本文:路宇,于立君,李国庆,冯建华,范惠子.重组人生长激素治疗生长激素缺乏症的疗效观察[J].生物磁学,2012(28):5494-5496.
作者姓名:路宇  于立君  李国庆  冯建华  范惠子
作者单位:哈尔滨医科大学附属二院儿内科黑龙江哈尔滨1500861
摘    要:目的:正确评价重组人生长激素(rhGH)治疗儿童生长激素缺乏症(GHD)的疗效。方法:GHD患儿47例,给予rhGH0.1U/(kg.d),疗程3个月,并对其疗效进行观察。结果:身高(height)由(122±17.67)cm增至(125.32±17.50)cm,生长速率(growthrate)由〈4cm/年增加到(10.40±3.74)cm/年。血清碱性磷酸酶(AKP)由(207±48.11)IU/L增至(261±45.29)IU/L。I型前胶原羧基端伸展肽(PICP)由(97.80±14.94)ng/ml增至(119.50±24.10)ng/ml值。肌酐(Cr)由(40.20±8.28)umol/L变为(36.50±8.33)umol/L值。结论:rhGH是治疗GHD有效的药物。

关 键 词:生长激素缺乏症  重组生长激素  儿童

The Therapeutic Effect of Recombinant Growth Hormone in Children of Growth Hormone Deficient
LU Yu,YU Li-jun,LI Guo-qing,FENG Jian-hua,FAN Hui-zi.The Therapeutic Effect of Recombinant Growth Hormone in Children of Growth Hormone Deficient[J].Biomagnetism,2012(28):5494-5496.
Authors:LU Yu  YU Li-jun  LI Guo-qing  FENG Jian-hua  FAN Hui-zi
Institution:(The Secord Affiliated Hospital of Harbin Medical University pediatric department,Harbin, Heilongjiang province, 150086, China)
Abstract:Objective: To investigate the therapeutic effect of recombinant growth Recombinant growth hormone(rhGH)in growth Hormone deficient (GHD)children before adolescence. Methods: This study included 47 children (30 boys and 17 girls)with GHD, who were treated With subcutaneous injections of rhGH 0.1 U/ (kg. d) before sleep for 3 months. Results: The mean height form ( 122± 17.67 ) cm to( 125.32± 17.50)cm, Growth rate by 〈4cm/year increased to (10.40± 3.74) / cm year, The mean AKP form(207± 48.11) 1U/L to (261± 45.29) 1U/L, The mean he PICP form (97.80± 14.94)ng/m to(119.50± 24.10) ng/ml, The mean Cr form(40.20± 8.28)umol/L to (36.50± 8.33). Conclusions: Recombinant growth Ilormone(rhGil) is an effective &rug for promoting height growth in GIlD children.
Keywords:Growth Hormone deficiency  Recombinant growth Hormone  Children
本文献已被 维普 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号