Livin及survivin表达与结肠癌发生、发展、转移及预后的关系

目的：探讨Livin及survivin表达与结肠癌发生、发展、转移及预后的关系。方法：采用免疫组化sP法检测100例结肠癌病人的癌、癌旁组织和正常结肠组织标本中Livin及survivin的表达，分析其与结肠癌发生、发展、转移及预后的关系，并通过随访研究其与5年生存率的关系。结果：Livin和Survivin在结肠癌组织中的阳性表达率均显著高于癌旁组织和正常结肠组织（P〈0．05），在结肠癌组织中的表达与患者年龄、性别、肿瘤的大小和分化程度均不具有相关性（P〉O．05），在有淋巴结及远处转移患者中高表达，与无转移者差异显著（P〈0．05）；Livin和Survivin表达阳性者5年生存率均明显低于表达阴性者（P〈0．05）；Livin和Survivin的表达无相关性。结论：Livin和Survivin在结肠癌的发生、发展和转移中起重要作用，对预后的判断具有一定的参考意义。

The Relationship between the Expression of Livin and Survivin and the Carcinogenesis, Progression, Metastasis and Prognosis of Colonic Cancer

Objective： To study the relationship between the expression of Livin and Survivin and the carcinogenesis, progression, metastasis and prognosis of colonic cancer. Methods：The expression of Livin and Survivin in 100 specimen of colonic cancer, paracance- rous, and normal colon tissue selected respectively were detected by using immunnohistochemistry SP method, and its relationship with the carcinogenesis, progression, metastasis and prognosis of colonic cancer, and with the 5 years survival rate were evaluated. Results： The positive expression rates of Livin and Survivin in colonic cancer were significantly higher than that in paracancerous, and normal colon tissue （P〈0.05）. The expression of Livin and Survivin in colonic cancer have no correlations with the following clinicopathological factors： age, gender, tumor size and differentiation level. But the positive expression rates of Livin and Survivin in the cases with lymph node and distant metastasis were observed significantly higher than those without metastasis. The 5 years survival rates in the cases with positive expression of Livin and Survivin were significantly lower than those with negative expression of Livin and Survivin. There were no correlations between expression of Survivin and expression of Livin. Conclusion：Survivin and Livin may play important roles in the carcinogenesis, progression and metastasis of colonic cancer, and also may provide an important prognostic implication.