超声造影在肝癌分级应用中的前瞻性研究

目的：利用超声造影研究高分化和低分化肝癌患者的肿瘤血流灌注情况，探讨超声造影在肝癌分级的诊断价值。方法：选择我院原发性肝癌（HCC）患者65例并根据活检肝细胞癌病变和肿瘤分级不同分为A组37例（高分化组）和B组28例（低分化组），对两组患者行超声造影检查，分析超声造影的血流灌注状态。结果：A组与B组病灶的到达时间（AT）、峰值时间（TTP）和峰值强度（PI）均存在显著的差异性（tAT=7．266，PAT=0．000；tTTP=5．966，PTTP=0．000；tPI=8．219，PPI=0．000）。A组与B组间的病灶增强时间（1）、增强斜率（2）、清除时间（3）、清除斜率（4）具有差异，并且差异具有统计学意义（t1=7．266，PI=0．000；t2=317，P2=0．000；t3=8．880，P3=0．000；t4=6．178，P4=0．000）。结论：超声造影可作为一种新型的肝癌分级方法，对于早期诊断肝癌和获得肿瘤分级具有很大的临床价值。

A Prospective Study of the Application of Contrast-enhanced Ultrasonography on Liver Cancer Classification

Objective： To study the tumor perfusion of patients with well differentiated and poorly differentiated hepatocellular carcinoma using contrast-enhanced ultrasonography in order to explore the value of contrast-enhanced ultrasonography in liver cancer classification. Methods：Sixty-five patients with primary hepatocellular carcinoma （HCC） in our hospital were divided into group A （well differentiated） with 37 cases and group B （poorly differentiated） with 28 cases according to the HCC lesions biopsy and tumor grade. Patients in two groups underwent ultrasound scanning. The perfusion status of contrast-enhanced ultrasonography was analyzed. Results： The differences of arrival time （AT）, time to peak（TTP） and peak intensity（PI） in group A and B were significantly different （tAT=7.266, PAT=0.000;t TTP =5.966, P TTP =0.000;tPI=8.219, PPI=0.000）. The differences of enhancement time （1）, enhancement slope （2）, outflow time （3） and clear slope （4） in group A and B were significantly different （t1=7.266,P 1=0.000 ;t2=8.317, P2=0.000;t3=8.880, P3 =0.000;t4=6.178,P4=0.000）. Conclusions： contrast-enhanced ultrasonography is hopefully to be a new method in liver cancer classification. It shows great value for early diagnosis of liver cancer and tumor grade.