汉族人群中血管紧张素转换酶抑制剂所致咳嗽与血管紧张素转换酶基因及缓激肽β2受体基因多态性的关系冰

目的：探讨汉族人群中血管紧张素转换酶抑制剂（ACEI）所致咳嗽与血管紧张素转换酶（ACE）基因及缓激肽β2受体（BDK-RB2）基因多态性的关系。方法：应用聚合酶链反应（PCR）方法。检测汉族人群中151例由于服用ACEI引起的咳嗽患者及151例未发生咳嗽的患者的ACEI／D及BDKRB2C／T的多态性，并采用紫外法检测ACE活性。结果：发现ACE基因分布在咳嗽组中II型为47．0％，ID型为42．4％，DD型为10．6％；无咳嗽组分别为39．7％、47．0％、13.3％，两组相比其差异具有统计学意义（P〈0．01）；BDKRB2基因分布在咳嗽组中CC型为21．3％，CT型为50．0％，TT型为28．7％，无咳嗽组分别为22．5％、47．7％、29．8％。两组相比其差异无统计学意义（P〉0．05）；咳嗽组ACE活性水平为（28．3±10．1）U／L]明显低于无咳嗽组（40．2±9．4）U／L]，两组相比其差异具有统计学意义（P〈0．01）。结论：汉族人群中ACEI所致咳嗽与ACE基因多态性及血清ACE水平有关，BDKRB2C／T与咳嗽间未发现有统计学意义的关联。

The Association between ACE Inhibitor （ACEI）-Induced Cough and the Polymorphism of Angiotensin Converting Enzyme （ACE） Gene and Bradykinin β2 Receptor（BDKRB2） Gene in Han Nationality

Objective： To investigate the association between angiotensin converting enzyme inhibitor （ACEI）-induced cough and the polymorphism of angiotensin converting enzyme （ACE） gene and bradykinin 62 receptor （BDKRB2） gene in Hart nationality. Methods： Polymerase chain reaction （PCR） was used to examine ACE I/D and BDKRB2 CT polymorphism in 151 ACEI-induced cough subjects and 151 no cough subjects in Han population. And UV-method was used to detect the ACE activity. Results：ACE gene distribution in the cough group： type II was 47.0%, ID genotype was 42.4%, DD genotype was 10.6%; Non-cough group were 39.7%, 47.0%, 13.3% respectively, and there was statistically significant difference between the two groups（P〈0.01）; BDKRB2 Gene distribution in the cough group： the CC genotype was 21.3%, CT genotype was 50.0%, TT genotype was 28.7%, non-cough group were 22.5%, 47.7%, 29.8% respectively, and there was not statistically significant between the two groups （ P〉 0.05）; The level of ACE activity in the Cough group （28.3 ± 10.1） U / L,] was significantly lower than non-cough group （40.2 ± 9.4） U / L,（P 〈0.01）.]. Conclusions： For ban population, ACEI-induced cough related to ACE gene polymorphism and serum ACE activity, and there was no statistically significant association between BDKRB2 C / T and cough.