| 蛹虫草培养液成分研究Ⅱ |
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| 引用本文： | 马骁驰,苟占平,张宝璟,邓卅,舒晓宏,张厚利,黄珊珊,刁云鹏,甄宇红.蛹虫草培养液成分研究Ⅱ[J].生物磁学,2009(20):3958-3961. |
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| 作者姓名： | 马骁驰 苟占平 张宝璟 邓卅 舒晓宏 张厚利 黄珊珊 刁云鹏 甄宇红 |
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| 作者单位： | [1]大连医科大学药学院,辽宁大连116044 [2]广东医学院药学院,广东省东莞523808 |
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| 基金项目： | 基金项目：大连市科技局资助（2008J23JH042）项目 |
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| 摘 要： | 目的：研究蛹虫草人工培养液的化学成分。方法：利用硅胶柱层析、制备薄层、SephadexLH-20、重结晶等方法分离、纯化单体化合物,并根据理化性质及光谱数据鉴定其化学结构。结果：分离并鉴定了8个化合物,分别为3,7,8-三甲基-异咯嗪（1）;琥珀酸（2）;胸腺嘧啶（3）;虫草素（4）;腺苷（5）;2吲哚乙丁二酰胺（6）;1（-5-羟甲基）-呋喃-3-羧基-β-咔啉（7）;5（-1-甲基丙基）-3,6-氧代-2-哌嗪乙酰胺（8）。结论：化合物1,6,7为首次从虫草属真菌中分离得到。
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| 关 键 词： | 蛹虫草 化学成分 培养液 |
Chemical Constituents of Culture Liquid of Cordyceps Mlitaris （L.） Link. |
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| MA Xiao-chi,GOU Zhan-ping,ZHANG Bao-jing,DENG Sa,SHU Xiao-hong,ZHANG Hou-li,HUANG Shah-shan,DIA O Yun-peng,ZHEN Yu-hong.Chemical Constituents of Culture Liquid of Cordyceps Mlitaris （L.） Link.[J].Biomagnetism,2009(20):3958-3961. |
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| Authors: | MA Xiao-chi GOU Zhan-ping ZHANG Bao-jing DENG Sa SHU Xiao-hong ZHANG Hou-li HUANG Shah-shan DIA O Yun-peng ZHEN Yu-hong |
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| Institution: | 1 School of Pharmacy, Dalian Medical University, Liaoning Dalian 116044, China; 2. School of Phanacology, Guangdong medical College, Dongguan 523808) |
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| Abstract: | Objective： To investigate the chemical constituents of the culture liquid of Cordyceps militaris （Fr.） Link. Methods： The chemical constituents of C. militaris were isolated and purified by the chromatographic methods such as column chromatography of silica gel, SephadexLH-20, and recrystallization, and then their structures were identified by physicochemical properties and spectral analysis. Results： ight known compounds were identified as, 7,8-trimethyl-iso-alloxazin （1）, succinic acid （2）, thymine （3）, cordycepin （4）, adenosine （5）, succinamide,N,N＇-bis-2-（3-indol）-ethyl] （6）, Flazin （7） and 5-（1- Methylpropyl ）-3,6-dioxo-2-piperazine acetamide （8）. respectively, on the basis of NMR spectra. Conclusion： compounds 1, 6 and 7 were isolated from Cordyceps for the first time. |
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| Keywords: | Cordyceps militaris Culture liquid Chemical constituent |
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