| NF-κB抑制剂治疗肺部炎症的研究进展 |
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| 引用本文： | 裴崇强,金鸣.NF-κB抑制剂治疗肺部炎症的研究进展[J].生物磁学,2009(20):3972-3975,3985. |
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| 作者姓名： | 裴崇强 金鸣 |
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| 作者单位： | 首都医科大学附属安贞医院-北京市心肺血管疾病研究所,北京100029 |
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| 基金项目： | 基金项目：国家自然科学基金资助项目（NO30572344）,北京市自然科学基金资助项目（NO.797225）,北京中医药重点学科项目资助（京中重V20）,科技部科技人员服务企业行动项目（sQ2009GJA2005624） |
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| 摘 要： | NF-κB信号转导途径与肺部的炎症性病变有密切关系,以此信号通路为作用靶点的抗炎治疗是近年研究的热点。本文综述了肺部各种细胞内NF-κB活化的作用以及应用NF-κB抑制剂治疗肺部疾病的研究进展,为急性肺损伤等肺部炎症的药物治疗研究提供参考依据。
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| 关 键 词： | NF-κB 信号转导 炎症 急性肺损伤 |
Progress in research of nuclear factor kappaB inhibitor in treatment of lung inflammation |
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| PEI Chong-qiang,JIN Ming.Progress in research of nuclear factor kappaB inhibitor in treatment of lung inflammation[J].Biomagnetism,2009(20):3972-3975,3985. |
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| Authors: | PEI Chong-qiang JIN Ming |
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| Institution: | (Beijing Anzhen hospital of the capital university of medical science Beijing institiute of heart lung and blood vessel diseases, Beijing 100029, China ) |
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| Abstract: | Signal transduction of nuclear factor kappa B is closely related to lung inflammation.Targeting on this signaling pathway is a hot research point for anti-inflammation drugs.In this paper,we reviewed the relationship between lung inflammation and nuclear factor kappa B,as well as the advance of nuclear factor kappa B inhibitor treated on lung disease.It is expected to give reference materials for the study of new anti-inflammation drugs. |
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| Keywords: | nuclear factor kappa B signal transduction inflammation acute lung injury |
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