注射用红花黄色素辅助治疗早期糖尿病肾病的临床效果观察

目的：观察注射用红花黄色素辅助治疗早期糖尿病肾病（diabetic nephropathy,DN）的临床效果。方法：选择2011年10月至2012年2月我院收治的早期DN患者86例,在患者知情同意的情况下随机分为对照组（n=42例）和观察组（n=44例）,对照组采取西医常规治疗措施,观察组在上述治疗措施的基础上加用注射用红花黄色素治疗,治疗4周后,比较两组患者的实验室检查指标及临床疗效。结果：治疗4周后,观察组患者的白蛋白排泄率（UAER）、尿β2微球蛋白（β2-MG）、血肌酐（Scr）、血尿素氮（BUN）、血甘油三酯（TG）、血胆固醇（TC）、低密度脂蛋白（LDL）均显著低于对照组,差异均具有统计学意义（P〈0.05）;对照组治疗总有效率为85.7%,观察组治疗总有效率为97.7%,两组患者治疗总有效率比较,差异具有统计学意义（P〈0.05）,观察组优于对照组。结论：注射用红花黄色素治疗辅助治疗早期DN可有效其提高临床疗效。

Observation on the Clinical Effect of Safflower Yellow Pigment Injection in the Adjuvant Ttreatment of Early Diabetic Nephropathy

Objective： To observe the clinical effect of safflower yellow pigment injection in the treatment of early diabetic nephropathy and research the way to improve the clinical effect. Methods： 86 patients with early diabetic nephropathy were collected and divided into the control group（n=42 cases） and observation group（n=44 cases） randomly, the control group were treated by the western conventional treatment measures,the observation group were added the safflower yellow pigment injection in the treatment,compared with that the laboratory indicators and clinical effect after four weeks＇ treatment. Results： After 4 weeks＇ treatment, the UAER, β2-MG,Scr, BUN, TG, TC and LDL in the observer groupwere all lower than those in the control group.The total effective rate was 85.7% in the control group, which was 97.7% in the observation group and was significantly higher（P0.05）, the observation group was better than the control group. Conclusion： In the treatment of early diabetic nephropathy by the western conventional treatment measures, safflower yellow pigment injection should be added to improve the clinical effect.