舌下特异性免疫治疗变应性鼻炎的临床疗效评价

目的：评价舌下特异性免疫治疗变应性鼻炎（allergicrhinitis，AR）的临床疗效，探讨提高AR疗效的治疗措施。方法：选择同期门诊及住院治疗的AR患者76例，在患者自愿的前提下，将患者分为对照组（n=40例）和观察组（n=36例），对照组患者给予常规药物治疗措施，观察组患者在上述治疗措施的基础上加行舌下特异性免疫治疗，治疗12个月后比较两组患者变异性鼻炎症状评分、变异性鼻炎体征评分、临床疗效及不良反应的发生情况。结果：治疗前，两组患者变异性鼻炎症状评分与体征评分比较。差异均无统计学意义（P〉0．05）；治疗12个月后，两组患者变异性鼻炎症状评分与体征评分均较治疗前显著降低，差异具有统计学意义（P〈0．05），且观察组患者变异性鼻炎症状评分与体征评分显著低于对照组，差异具有统计学意义（P〈0．05）。对照组和观察组的治疗总有效率分别为为87．5％和100．0％，差异具有统计学意义（P〈0．05）。此外，两组治疗期间不良反应的发生率比较差异无统计学意义（P〉0．05）。结论：舌下特异性免疫治疗治疗AR，其临床疗效确切且安全可靠，值得推广和深入研究。

The Evaluation of Clinical Efficacy of Sublingual Immunotherapy in the Treatment of Allergic Rhinitis

Objective： To evaluate the clinical effect ofsublingual immunotherapy （SLIT） in the treatment of allergic rhinitis（AR） and investigate the treatment measures to improve the clinical effect of AR. Methods： 76 allergic rhinitis patients were collected and randomly divided into the control group（n--40） and the observation group（n=36）, the allergic rhinitis symptom score, allergic rhinitis signs score, clinical effect and incidence of adverse reactions after twelve months＇ treatment were observed and compared between two groups. Results： Before treatment, no significance of allergic rhinitis symptom score and allergic rhinitis signs score was found between the two groups （p〉0.05）; after 12-month treatment, the allergic rhinitis symptom score and allergic rhinitis signs score of both groups were significantly lower than before treatment（P〈0.05）, and they are significantly lower in observaton group than those in control group（P〈 0.05）. The total efficiencyof control group and observation group were 87.5% and 100.0% respectively （P 〈0.05）. In addition, no significance ofincideee rate of adverse reactions was found between the two groups （P〉0.05）. Conclusion： SLIT method was effective and safe to treat A_R, it, was worth being popularized and deeply researched.