铜绿假单胞菌注射液联合顺铂治疗消化道恶性腹腔积液的临床研究

目的：比较铜绿假单胞菌注射液联合顺铂与单纯使用顺铂治疗消化道恶性腹腔积液的疗效。方法：将250例消化道恶性中等量以上腹腔积液患者分为对照组和实验组各125例。所有患者行穿刺置管引流术，地塞米松预防发热，予盐酸利多卡因预防腹痛。铜绿假单胞菌注射液每周两次，顺铂每周一次，疗程一周，最多两个疗程。结果：实验组患者有效率为85．6％，其中，完全缓解40例，部分缓解67例。对照组例患者有效率为52％，其中，完全缓解24例，部分缓解4l例。两组比较差异有统计学意义（x2=32．87，P〈0．05）。实验组患者WHO体力状态评分（1分和2分）为104例，有效率为83．2％；对照组患者WHO体力状态评分（1分和2分）为72例，有效率为57．6％。两组比较差异有统计学意义（x2=19．67，P〈0．05）。结论：铜绿假单胞茵注射液联合顺铂腹腔内给药治疗消化道恶性腹腔积液。临床疗效显著。

Clinical Study of Pseudomonas Aeruginosa Combined with Cisplatin in Patients with Malignant Ascites

Objective： To evaluate the clinical efficacy ofpseudomonas combined with cisplatin on the treatment of the malignant ascites. Methods： 250 patients with moderate or more malignant ascites were included in this study and divided into the experimental group and the control group. The patients in the experimental group were given the pseudomonas aeruginosa combined with the cis- platin, while the patients in the control group were given cisplatin. After the abdominal paracentesis and catheterization were performed, the patients were given drug. Dexamethasone was used to prevent fever and lidocaine hydrochloride to prevent abdominal pain. Pseu- domonas aeruginosa was injected 2 times per week and cisplatin 1 time per week until one week. Results： The effective rate in the experi- mental group was 85.6%, which including 40 cases in complete remission and 67 cases in partial remission. The effective rate in the con- trol group was 52% including 24 cases in complete remission and 41 cases in partial remission with statistically significant differences（x2 =32.87, P〈0.05）. According to the WHO performance status score, the effective rate in experimental group was 83.2%（104 cases）, and 57.6% in the control group（72 cases）. There were statistically significant differences between two groups（x2=1 9.67, P〈0.05）. Conclusions： It is valuable to apply the pseudomonas aeruginosa combined with cisplatin on the treatment of the malignant ascites.