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氟比洛芬酯联合地佐辛用于甲状腺手术术后镇痛的研究
引用本文:张锐,于淼舒,李晟琰,孙鑫,任铭,吴晓秋.氟比洛芬酯联合地佐辛用于甲状腺手术术后镇痛的研究[J].生物磁学,2013(24):4734-4737.
作者姓名:张锐  于淼舒  李晟琰  孙鑫  任铭  吴晓秋
作者单位:中航工业哈尔滨二四二医院麻醉科黑龙江哈尔滨150066
摘    要:摘要目的:研究氟比洛芬酯与地佐辛联合应用对于甲状腺手术患者术后的镇痛效果。方法:选择90例ASAI或II级甲状腺手术的患者(包括结节性甲状腺肿,甲状腺功能亢进,甲状腺癌)。年龄21.59岁,一般状态良好,随机分为三组:(FD组)氟比洛芬酯+地佐辛组,(F组)氟比洛芬酯组,(D组)地佐辛组,每组30例。各组于手术结束前30rain分别缓慢静脉输注药物,FD组:氟比洛芬酯50mg+地佐辛5mg;F组:氟比洛芬酯50mg;D组:地佐辛5mg。然后各组分别泵入不同的药物,FD组:氟比洛芬酯200mg+地佐辛30mg,F组:氟比洛芬酯200mg,D组:地佐辛30mg,均以生理盐水稀释至100mL,以2ml/h的速率持续泵注48小时。分别记录各组各时间点:(T1)术后2h、(T2)术后6h、(T3)术后12h、(T4)术后24h、(T5)术后48h的心率(HR)、血氧饱和度(SPO:)及各时间点的疼痛评分(VAS)、镇静评分(Ramsay),并记录出现的恶心、呕吐、眩晕等并发症的例数。结果:FD组、F组血流动力学较之D组平稳,D组出现一过性sP02下降。术后VAS评分D组明显高于FD组和F组(P〈0.05),Ramsay评分FD组、F组低于D组(P〈0.05)。结论:在甲状腺手术术后镇痛的研究中,氟比洛芬酯与地佐辛联合应用,并发症少,镇痛良好,VAS、Ramsay等各项评分优于单纯应用氟比洛芬酯与地佐辛组。

关 键 词:氟比洛芬酯  地佐辛  甲状腺手术  镇痛

Flurbiprofen Axetil Combined Dezocine for Thyroid Surgery Postoperative Analgesia
ZHANG Rui,YU Miao-shu,LI Sheng-yan,SUN Xin,REN Ming,WU Xiao-qiu.Flurbiprofen Axetil Combined Dezocine for Thyroid Surgery Postoperative Analgesia[J].Biomagnetism,2013(24):4734-4737.
Authors:ZHANG Rui  YU Miao-shu  LI Sheng-yan  SUN Xin  REN Ming  WU Xiao-qiu
Institution:(Department of Anesesia 242 Hospital of haerbin, Heilongiiang, Harbin, 150066, China)
Abstract:Objective: To study the effect of flurbiprofen ester combined with dezocine on postoperative analgesic in patients with thyroid surgery. Methods: 90 cases of ASA I or class II thyroid surgery included nodular goiter, hyperthyroidism, thyroid cancer. Aged 21-59 years, generally in good condition, were randomly divided into three groups: fturbiprofen axetil dezocine (FD group), flurbiprofen ester (F group), dezocine (D), each30 cases. 30 min before the end of surgery, drugs were slow intravenous infused: FD group, flurbipro- fen axetil 50 mg + to dezocine 5 mg; F Group, flurbiprofen axetil 50 mg; D Group, dezocine 5 mg. And then patients in each group were pumped into the different drugs: the FD Group, the flurbiprofen axetil 200 mg + dezocine for 30 mg; F group, flurbiprofen axetil 200 rag; group D, dezocine 30 mg, so as tosaline solution was diluted to 100 mL; the rate of continuous infusion was 2 ml / h for 48 hours. Time point of recording was: (T1) after 2 h (T2) after 6 h (T3) after 12 h (T4) after 24 h, 48 h after operation (T5); and mean arterialpressure (MAP), heart rate (HR), oxygen saturation (SPO2) and the point in time the pain score (VAS), sedation score (Ramsay), and record the number of cases appears nausea, vomiting, dizziness and other complications were recorded. Results: Hemodynamics in FD and F group were more stable than that in D group, SPO2 in D group had transient drop. The postoperative VAS scorein D group was significantly higher than that in the FD group F (P 〈0.05), Ramsay score in FD and F group than that in group D (P 〈0.05). Conclusion: For analgesia in thyroid surgery, flurbiprofen axetil combined with dezocine have fewer complications and a good analgesia, and VAS and Ramsay score are better than that with the simple application of flurbiprofen axetil or dezocine.
Keywords:Flurbiprofen axetil  Dezocine  Thyroid surgery  Analgesia
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