外源性磷酸肌酸对重度窒息新生儿血清S-100B蛋白及NSE水平的影响 |
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引用本文: | 张玉晶,赵霞霞,田执梁,姜伟,杨艳辉.外源性磷酸肌酸对重度窒息新生儿血清S-100B蛋白及NSE水平的影响[J].生物磁学,2011(21):4040-4042. |
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作者姓名: | 张玉晶 赵霞霞 田执梁 姜伟 杨艳辉 |
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作者单位: | 哈尔滨医科大学附属第二医院,黑龙江哈尔滨150086 |
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基金项目: | 黑龙江省卫生厅课题(2007-324) |
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摘 要: | 目的:探讨外源性磷酸肌酸对重度窒息新生儿血清S-100B蛋白和特异性神经元烯醇化酶含量(NSE)的影响。方法:重度窒息的新生儿40例,随机分为两组,常规治疗组21例,给予一般治疗(氧疗、支持、对症)和胞二磷胆碱治疗。磷酸肌酸治疗组19例,在常规治疗基础上,生后12h内给予磷酸肌酸治疗1g/d),另外同期住院的新生儿湿肺和黄疸患儿14例为正常对照组。均与生后48h和生后10天取血检测血清S-100B蛋白和NSE含量。并于生后第14天进行新生儿行为神经测定(NBNA评分)。结果:磷酸肌酸治疗组和常规治疗组患儿生后48h血清S-100B蛋白和NSE含量无显著差异(※P〉0.05,※P〉0.05),与正常对照组比较差异具有显著性(△P〈0.05,△P〈0.05),生后10天血清S-100B和NSE含量在常规治疗组患儿和磷酸肌酸组相比具有显著差异,磷酸肌酸治疗组两者明显下降(※P〈0.05,※P〈0.05)。生后三周的行为神经评估(NBNA评分)〈35分者所占百分比磷酸肌酸治疗组27%与常规治疗组组53%比较,差异均具有显著性意义(x2=6.112,※P〈0.05)。结论:磷酸肌酸用于治疗新生儿缺氧缺血性脑病能够改善脑的能量代谢,降低脑损伤的程度,改善神经行为,降低致残率。
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关 键 词: | 磷酸肌酸 缺氧缺血 S-100 NSE NBNA评分 |
Effect of Exogenous Phosphocreatine on the Level Changes of S-100B Protein and NSE in Serum with Serious Asphyxia in Newborn |
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Institution: | ZHANG Yu-jing, ZHAO Xia-xia, TI AN Zhi-liang, JIANG Wei, YANG Yun-hui (Harbin medical university of the second affiliated hospital, 150086, Harbin, China ) |
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Abstract: | Objective: To observe the effect of exogenous phosphocreatine on the level changes of S100b protein and NSE In serum with serious hypoxia -ischemic encephalopathy in newborn infants. Methods: 40 serious asphxia newborn were randomly devided into two groups: routin therapy group(21 newborns), routin treatment with oxygen ,nutrition and citicoline(CTL).The treatment group(19 newboms) were given exogenous phosphocreatine (12h after born, 1 g/d) besides conventional therapy which was given in control only. The control group (14 newborn)without asphyxia newborns. The content of S100b protein and NSE in serum were measured using enzyme-linked immuradsorbent assay (ELISA) after 48h and 10 days. The newborns in both groups were assessed with neurological fimction, the NABA scores was recorded. Results: The level of NSE and S100B protein In serum in the treatment group and routin theray group in 48h were no significantly difference ( ※P〉0.05, ※P〉0.05). As compared with control group it was significantly difference ( △P〈0.05,△P〈0.05 ). The level of NSE and S-100B protein In serum after 10 days between two group were significantly difference, the treatment group were significantly decreased (※P〈0.05, ※P〈0.05). The NBNA score〈 35 point after 3 weeks account for 27.0% in treatment group and 53% in control group,which had significantly difference (x2=6.112, ※P〈0.05). Conclusions: Exogenous phosphocreatine can protect brain tissure and improve the energetic metabolism of the brain cell, can lessen cerebral ischemic injury,which can decrease disability rate and improve neurological function. |
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Keywords: | Exogenous phosphocreatine Hypoxia -ischemic Encephalopathy NSE S 100b protein NBNA score |
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