糖化血红蛋白与糖尿病及其并发症的关系

目的：探讨糖化血红蛋白（HbAlc）与糖尿病诊断、疗效评价及并发症的关系。方法：选择2型糖尿病患者250例和健康体检者150例，分别测定空腹血糖（FPG）、2h血糖（2hPG）及糖化血红蛋白（HbAlc），统计学分析HbAlc与FPG、2hPG的相关性；分析HbAlc与糖尿病并发症发生的关系。结果：糖尿病组FPG、2hPG及HbAlc水平均显著高于对照组（P〈0．01）；糖尿病伴有并发症患者的HbAlc明显高于无并发症者（P〈0．05），HbAlc水平与糖尿病并发症的发生率存在高度相关性（P〈0．01）。结论：检测外周血中HbAlc水平对2型糖尿病诊断、疗效评价具有重要，临床价值，控制糖化血红蛋白对预防糖尿病并发症的发生具有重要意义。

The Value of Glycosylated Hemoglobin 1 c Detection in Diagnosis and Complications of Diabetes in Diabetes

Objective： To investigate the Glycosylated hemoglobin l c （HbAlc） test for diagnosis of diabetes, efficacy evaluation and prediction of complications in clinical value. Methods： Choose patients with type 2 diabetes mellitus （T2DM group） 250 cases and healthy subjects （ control group） 150 patients, measured by fasting plasma glucose（FPG）, 2 hour plasma glucose （ 2bPG ） and glycated hemoglobin （HbAlc）, then compared analysis of HbAlc and FPG, 2hPG relationship, and analyzed the relationship between HbAlc and the diabetes related complications. Results： Diabetes group FPG, 2hPG and HbAlc were significantly higher than control group （P 〈 0. 01）; H bAlc levels in the diabetic complications group were significantly higher than patients with no complications （P 〈 0. 05）. There were high correlation between H bAlc level and the incidence of complications of diabetes （P 〈0. 01）. Conclusion： Detection ofH bAlc levels in diabetic patients has important clinical value in the diagnosis, evaluation of efficacy, and it was important to control the glycated hemoglobin levels for the prevention of diabetes complications.