THP在早期非肌层侵润性膀胱癌定位诊断与治疗中的临床应用

目的：探讨THP在早期非肌层侵润性膀胱癌定位诊断与治疗中的临床应用价值。方法：已诊断非肌层侵润性膀胱癌患者45例，术中均实行THP膀胱灌注，灌注后15min置入膀胱镜，观察膀胱内粘膜，将THP橙色染色区域作为实验组进行活检，其他未染色区域作为对照组随机活检，活检组织行病理检查。TUR—BT术后将45例患者随机分为3组。在不同的时间点开始灌注（术后即刻、术后6小时、术后7天），比较复发率和平均复发时间。结粜：两组间比较具有统计学意义（P〈0.05）恶性粘膜吸收THP敏感度和特异度分别为100％、63．5％；TUR-BT术后即刻灌注及6小时后灌注的总复发率明显低于术后7天灌注，差异有统计学意义（P〈0．05）。结论：THP对非肌层侵润性膀胱癌早期定位诊断准确、安全性好，同时术后早期灌注THp可以降低肿瘤的复发率，值得临床推广。

Clinical Application of Localization Diagnosis and Treatment in the Early Non-Muscle Invasive Bladder Cancer with THP

Objective： To discuss the value of clinical application in the early non-muscle invasive bladder cancer with THP. Methods： 45 patients which had been diagnosised non-muscle invasive bladder cancer were selected as research subjects. The patients received intravesical treatment with THP in operation and observated the bladder mucosa 15 minutes after intmvesical treatment with cystoscopy. THP orange stained area was biopsied as the experimental group for pathological examination and other unstained area as the control group. 45 patients after TUR-BT were divided into 3 groups with randomized. The patients received intravesical treatment at different times （immediately after TUR-BT, 6 hours after TUR-BT, 7 days after TUR-BT）. Then the recurrence rate and average recurrence time were compared. Results： The comparison of results between the two groups had statistical significance （P〈0.05）. The sensitivity and specificity for THP absorbtion by malignant mucosa were 100% and 63.5%, respectively. Overall recurrence rate of immediately after TUR-BT and 1 day after TUR-BT obviously lower than 1 week after TUR-BT.There were statistical significance （P〈0.05）. Conclusion： THP is exactly and good security in early localization diagnosis of non-muscle invasive bladder cancer. And the early postoperative infusion can reduce the rate of tumor recurrence rate. It is worthy of popularization and application.