| 子宫内膜癌组织中PTEN和MTA1蛋白的表达及其相关性 |
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| 引用本文： | 桂玲,张克强,王静.子宫内膜癌组织中PTEN和MTA1蛋白的表达及其相关性[J].生物磁学,2011(19):3700-3702. |
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| 作者姓名： | 桂玲 张克强 王静 |
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| 作者单位： | 湖南省肿瘤医院,湖南长沙410013 |
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| 摘 要： | 目的：探讨子宫内膜癌组织中PTEN和MTA1表达及其与子宫内膜癌生物学行为之间的关系。方法：采用免疫组化SP法检测130例子宫内膜癌和40例正常宫内膜组织中PTEN和MTAl1的表达水平，并分析两者在子宫内膜癌中的相关性。结果：子宫内膜癌组织中PTEN、MTA1阳性表达均显著高于正常子宫内膜组织（P〈0．01）；PTEN与MTAI在子宫内膜癌组织中的表达呈负相关（r=0．35，P〈0．05）。结论：PTEN和MTA1表达与子宫内膜癌的发生、发展及生物行为密切相关，且两者表达存在负相关性。
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| 关 键 词： | 子宫内膜肿瘤 PTEN MTA1 免疫组织化学 |
Expression of PTEN and MTA1 and their Correlation in the Endometrial Cancer |
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| Institution: | GUI Ling, ZHANG ke-qiang, WANG ring (Department of Obstetrics and Gynecology, Tumor Hospital of Hunan Province, Changsha 410013, China) |
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| Abstract: | Objective： To explore the expression of PTEN and MTA1 and their correlation in the endometrial cancer. Methods： In 130 cases ofendometrial cancer and 40 eases of normal endometrial, the expression of PTEN and MTA1 was examined with immunohistochemistry SP method and their correlation. Results： The expression of PTEN and MTA1 in endometrial cancer was higher than that in normal endometrial. （P〈0.01）. PTEN expression levels in endometrial cancer were inversely correlated with MTA1 protein. （r= -0.35, P〈0.05）. Conclusion： Expression of PTEN expression and MTA1 is inversely correlated with the development and progression of endometrial cancer. |
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| Keywords: | Endometfial cancer PTEN MTA 1 Immunohistoehemistry |
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