围术期应用肼苯哒嗪预防疝修补术后慢性疼痛的研究

目的：探讨肼苯哒嗪对疝修补术后患者慢性疼痛发生率的影响。方法：选择单侧腹股沟疝患者48人，随机分为实验组（T组）和对照组（c组）各24例，在术前3天至术后4天共7天内接受药物或安慰荆治疗。其中T组每日两次，每次10mg肼苯哒嗪，C组同样方式给予安慰剂。测量患者术后4天内的平均动脉）Z（MAP）、心率（HR）、NRS急性疼痛评分以及术后3月、6月S—LANSS慢性疼痛评分。结果：T组患者术后MAP明显低于C组（P〈0．05），HR两组相比无差异（P〉0．05）；两组患者术后急性疼痛程度相比无统计学差别（P〉0．05）；T组患者在术后3月和6月慢性疼痛发生率明显低于C组（P〈0．05）。结论：常规剂量肼苯哒嗪可以用于术后患者，对疝修补术后急性疼痛无影响，但可以明显降低术后慢性疼痛的发生率。

Perioperative Administration of Hydralazine Prevents Postoperative Chronic Pain After Hemiorrhaphy

Objective： To explore the role of hydralazine in prevention of postoperative chronic pain. Methods： 48 patients with herniorrhaphy were randomly divided into Test group （T group, n=24） and Control group （C group, n=24）. The patients in T group were treated with 10 mg hydralazine BID, and the patients in C group was administered with placebo in the same manner. The MAP, HR, NRS score were measured during the first four days after operation, and S-LANSS scores were reported by every available patient at 3 and 6 months postoperatively. Results： The MAP level oft group patients was significantly lower than that of C group （P〈0.05）; HR in the two groups has no signicant difference（P〉0.05）.There was no significant differences of NRS scores in the two groups （P〉0.05）. The incidences of postoperative chronic pain was obviously lower in T group than those in C group （P〈0.05）. Conclusions： Hydralazine can obviously decrease the incidence of postoperative chronic pain rather than the acute pain in patients after hemiorrhaphy.