Visfatin、IL-6、TNF-α与2型糖尿病的相关研究

目的：探讨血浆visfatin、IL-6、TNF-α与2型糖尿病的关系。方法：2型糖尿病患者60例,正常对照组30例。根据体重指数分为肥胖组和非肥胖组。检测空腹血浆胰岛素、糖化血红蛋白、血糖、血脂、血压、visfatin、TNF-α、白介素-6等。计算体重指数、腰臀比值及稳态模型胰岛素抵抗指数（HOMA-IR）。结果：2型糖尿病组血浆visfatin、IL-6、TNF-α水平显著高于正常对照组（P〈0.05）;2型糖尿病组与正常肥胖组比较,糖尿病非肥胖组visfatin（301.60±58.07）明显升高,糖尿病肥胖组visfatin（336.68±37.61）、TNF-α（3.58±1.10）明显升高（P〈0.05）。多元线性相关分析表明,在肥胖的2型糖尿病患者中血浆TNF-α与糖化血红蛋白显著正相关,血浆IL-6与血糖（FPG）显著正相关,血浆visfatin与腰臀比值（WHR）显著正相关（P〈0.05）。结论：visfatin、IL-6、TNF-α的变化可能对2型糖尿病的发生、发展具有一定的作用。

The Study of IL-6,TNF-α and Visfatin in Type 2 Diabetes Mellitus

Objective： To investigate the relationship among plasma visfatin,IL-6,TNF-α with type 2 diabetes mellitus（T2DM）.Methods： 60 T2DM patients were selected as T2DM group and 30 healthy subjects as control group.According to body mass index（BMI） they were divided into two groups： obese group and non-obese group.Visfatin,IL-6,TNF-α,free insulin,HbA1c,free glucose,blood pressure,lipids were measured and the waist-to-hip ratio（WHR）,BMI,homeostasis model assessment of insulin r esistance（HOMA-IR） were calculated.Results： Visfatin,IL-6 and TNF-α level was significantly higher in T2DM group than that in control group（P0.05）;Visfatin（301.60±58.07）level was significantly higher in non-obese group of T2DM group than that in obese group of con-trols.Visfatin（336.68±37.61）and TNF-α（3.58±1.10）level was significantly higher in obese group of T2DM group than that in obese group of controls;The multiple logistic regression anlysis showed that,the TNF-α to glycosylated hemoglobin,the IL-6 to blood sugar,the visfatin levels was positively related to waist-hip ratio（WHR） in obese T2DM group（P0.05）.Conclusions： The change of plasma IL-6,TNF-α and visfatin level may play a role in the pathogenesis and develonpment of Type 2 Diabetes Mellitus.