北京市2010年手足口病死亡病例流行病学及临床特征分析

目的：通过描述2010年北京市手足口病死亡病例的流行病学特点和临床特点，分析手足口病重症病例发生死亡的危险因素，为防制手足口病，减少手足口病的死亡提供科学依据。方法：采用现况描述及病例对照研究的方法，对2010年北京市手足口病死亡病例的特点进行分析。结果：2010年北京市共报告18例手足口病死亡病例，88．9％分布在5．8月份；死亡病例的男女比例为3．5：1；年龄均小于4岁；流动人口聚集区的死亡病例较多；散居儿童及外地户籍儿童比例高，分别为83．3％和94．4％。死亡病例均出现出疹、发热及神经精神系统症状，整体精神状况，呼吸功能指标以及循环系统受累明显。与重症痊愈病例相比，感染EV71型病毒是发生死亡的危险因素（x2=4．774，P=0．029）。结论：手足口病死亡病例分布与重症病例分布基本一致。应对流动人口聚集地区的4岁以下婴幼儿重症病例进行重点防控。

Epidemiological and clinical characteristics of hand-foot-mouth disease deaths in Beijing 2010

Objective： To exmine the epidemiological and clinical characteristics of hand-foot-mouth disease deaths case in Bei- jing 2010, to explore the risk factors of intensive case development of deaths case, to provide the treasures data for preventing and control hand-foot-mouth disease deaths case. Methods： Use monitoring data of hand-foot-mouth disease deaths case and case-control study,was analyze the characteristic of deaths case. Results： There were 18 reportrd hand-foot-mouth disease deaths case in Beijing 2010. 88.9% deaths case was from May to August; male female ratio of deaths case was 3.5：1; age of patients was less than 4 years old for all of the case;most case were reported in floating of urban-rural population community;more deaths case were seen in scattered children and non- local census register children,and the rate was 83.3% and 94.4%. All of deaths case were suffered fi＇om rash, fever and mentally psychia- tric symptoms;overall mental status, respiratory function, and circulatory system were clear indicated. Compared with intensive recovered case, the risk factors of deaths case was infected with EV71 type virus （x2=4.774, P=0.029）. Conclusion： Distribution of HFMD deaths case were consistent with severe disease.Prevention and control strategies should focus on the children under 4 years, especially those live in floating population community.