冠心病患者血清sCD40L水平及其与hs—CRP关系研究

目的：研究冠心病患者血清sCD40L和hs-CRP临床特点及其关系，探讨其在冠心病预测和治疗中的意义。方法：采用夹心法酶联免疫吸附测定分析法及微粒子增强透射免疫分析法分别对对照组15例、稳定型心绞痛（SAP）组27例、不稳定型心绞痛（UAP）组35例及急性心肌梗死（AMI）组14例受试者血清sCD40L和hs—CRP水平进行检测，并观察其与冠脉狭窄程度的相关性。结果：1）、血清hs-CRP水平：SAP组、UAP组、AMI组呈依次递增（AMI组比UAP组、UAP组比SAP组P〈0．05．AMI组、UAP组比对照组（P〈0．01）；SAP组与对照组血清hs—CRP水平相似；2）、血清sCD40L水平：AMI组及UAP组血清sCD40L水平高于SAP组和对照组（P〈0．01），AMI组与UAP组之间、SAP与对照组间没有统计学差异；3）、相关分析显示血清sCD40L水平与hs-CRP水平显著相关（r=0．787，P〈0．0001），两者均与冠脉狭窄程度无相关性。结论：血清hs-CRP、sCD40L水平升高与冠心病临床表现类型和病情是否稳定有关，与冠状动脉狭窄程度无关，此两项指标能够用于冠心病病情不稳定性的判断和预测。

Study of Serum sCD40L Level and its Correlation to hsCRP in Coronary Heart Disease

Objective： To study the serum levels of sCD40L and hs-CRP in patients with coronary heart disease, and to investigate the clinical significance of them. Methods： 14 patiens with AMI, 35 patiens with UAP,27 patients withSAP, and 15 controls entered this study. The serum levels of sCD40L and hs-CRP were measured by enzyme linked immunosorbent assay and particle-enhanced immunonephelomerty respectively. Results： （1）. The serum levels of hs-CRP significantly increased fi＇om SAP group and UAP group to AMI group（P〈0.05）, while SAP group had a similar hs-CRP level compared with control group; （2）. The serum levels of sCD40L were higher in AMI group and UAP group compared with SAP group and control group （P〈0.01）. （3）. Correlation analysis showed that the serum level of sCD40L was significantly correlated with that of hs-CRP （r=0.787, P〈0.0001）.The levels of hs-CRP and sCD40L had no correlation with stenosis extent of coronary artery segment. Conclusion： Elevated levels ofsCD40L and hs-CRP suggest the unstable condition of coronary heart disease. The serum level ofhs-CRP has direct correlation with the level ofsCD40L, sCD40L might be considered a suitable markers for identifying patients at risk for active cardiovascular events in addition to hs-CRP.