| 提高动物乳腺生物反应器表达水平的策略 |
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| 引用本文： | 李志沭,仇志琴,黄玉政,胡礼仪,成勇.提高动物乳腺生物反应器表达水平的策略[J].生物磁学,2009(15):2977-2979,2959. |
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| 作者姓名： | 李志沭 仇志琴 黄玉政 胡礼仪 成勇 |
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| 作者单位： | [1]江苏省沭阳人民医院,江苏沭阳223600 [2]南京医科大学附属无锡二院,江苏无锡214002 [3]江苏省血吸虫病防治研究所,卫生部重点实验室,江苏无锡214064 [4]扬州大学,江苏省转基因制药工程研究中心,江苏扬州225009 |
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| 基金项目： | 基金项目：江苏省卫生厅科研项目（NO.X00736）,江苏省卫生厅重点开放课题（WK0511） |
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| 摘 要： | 在转基因动物乳腺生物反应器研究中，组织特异性表达水平、表达率和表达定位性是决定性的指标。因此，高效表达乳腺生物反应器的制备是许多研究者要实现的目标，也是走向产业化的基本要求。本文从基因构件、动物基因转移方面叙述了如何提高乳腺生物反应器表达水平、增强表达特异性及表达率，着重探讨如何提高动物乳腺生物反应器表达水平。
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| 关 键 词： | 转基因动物 乳腺生物反应器 基因表达 |
Strategies of Enhancing the Expression in Animal＇s Mammary Gland Bioreactor |
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| LI Zhi-shu,QIU Zhi-qin,HUANG Yu-zheng,HU Li-yi,CHENG Yong.Strategies of Enhancing the Expression in Animal＇s Mammary Gland Bioreactor[J].Biomagnetism,2009(15):2977-2979,2959. |
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| Authors: | LI Zhi-shu QIU Zhi-qin HUANG Yu-zheng HU Li-yi CHENG Yong |
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| Institution: | 1 Shuyang People＇s Hospital, Shuyang, Jiangsu, 223600; 2 Nanjing Medical University AFfiliated Wuxi Second Hospital, Wuxi, Jiangsu, 214002; 3 Jiangsu Institute of Parasitic Diseases, Key Laboratory on Technology for Parasitic Diseases Prevention and Control, Ministry of Health. Wuxi, Jiangsu, 214064; 4 Yangzhou University, Engineering, Research Center for Transgenie Animal Pharrning, Yangzhou Jiangsu, 225009) |
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| Abstract: | Mammary gland bioreactor that was developed from animal transgenic technology has become a hotspot in life sci- ences. It is a new property that animal＇s mammary can produce human recombinant pharmaceutical protein and it will also become one of key industries in our country. This paper briefly reviews the basic concepts of the mammary gland bioreactor, discusses the problems of gene expression existed in gland bioreactor and its industrial prospects in the future. |
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| Keywords: | Transgenic animal Mammary gland bioreactor Gene expression |
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