| 锰超氧化物歧化酶对神经系统作用的研究综述 |
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| 引用本文： | 刘克丹,石铁军.锰超氧化物歧化酶对神经系统作用的研究综述[J].生物磁学,2009(14):2748-2751. |
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| 作者姓名： | 刘克丹 石铁军 |
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| 作者单位： | 哈尔滨工业大学生命科学与工程系,黑龙江哈尔滨150080 |
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| 摘 要： | 锰超氧化物歧化酶（SOD2）是线粒体基质酶，作为细胞内氧自由基的清除剂，SOD2与氧化应激相关的神经系统疾病密切相关。本文从SOD2的一般生物学特性、在神经系统中的作用以及在临床上的应用等方面对其近期的研究成果和未来发展趋势进行了综述。
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| 关 键 词： | 锰超氧化物歧化酶 氧化应激 背根神经节神经元 坐骨神经切断术 |
Role of Manganese Superoxide Dismutase in Nervous System |
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| LIU Ke-dan,SHI Tie-jun.Role of Manganese Superoxide Dismutase in Nervous System[J].Biomagnetism,2009(14):2748-2751. |
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| Authors: | LIU Ke-dan SHI Tie-jun |
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| Institution: | (Department of Life Sciences and Engineering, Bio-X Center, Harbin Institute of Technology, 150080, Harbin, China ) |
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| Abstract: | Manganese superoxide dismutase （SOD2） is a matrix enzyme expressed in mitochondria. SOD2 is a known free radical scavenger, and has been shown to play a role in several nervous system diseases. In this review we mainly focus on the regulation of SOD2 in primary sensory neurons after nerve injury, and summarize recent discoveries and future developments that highlight the potential role of SOD2 as a therapeutic target for the treatment of chronic pain. |
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| Keywords: | Manganese superoxide dismutase Oxidative stress Dorsal root ganglion Axotomy |
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