胃癌中HER-2蛋白和NF-KB蛋白的表达及其临床意义

目的：探究人类表皮生长因子受体-2（HER-2）和核因子．KB（NF-KB）在胃癌中的表达及二者之间的关系。方法：收集检测武汉大学附属中南医院2007年1月-2009年12月75例胃癌手术切除的组织和22例癌旁正常胃组织，HER-2和NF—KB的表达检测采用免疫组织化学sP法；分析其与胃癌临床病理特征的关系以及二者之间的相关性。结果：胃癌中HER-2和NF-KB的阳性率分别为24．00％（18／75）和62．67％（47／75）；两者与年龄、性别均无相关性，而与分期、分级和是否转移相关（P〈0．05）；HER-2与肿瘤大小无相关性，但NF—KB与肿瘤大小相关（P〈0．01）。HER-2阳性时NF-KB的阳性率为94．44％（17／18），HER-2阴性时NF-KB的阳性率为52．63％（30／57），两者的表达有显著相关性（x2=8．514，P〈0．01）。结论：胃癌中NF-KB、HER-2蛋白的表达具有相关性，在胃癌的发生发展中具有重要作用。

Expression and Clinical Significance of HER-2 and NF-KB in Gastric Cancer

Objective： To investigate the expression and their relevance of human epidermal growth factor receptor 2 （HER-2） and Nuclear factor-Kb （NF-KB） in gastric cancer. Methods： The expression of HER-2 and NF-KB protein were detected by SP immunohistochemical method in 75 gastric cancer specimens （observed group） and 22 normal gastric tissue collected during January 2007 to December 2009. The clinical pathological data was statistically analyzed. Results： The positive rate of HER-2 and NF-KB in the observed group were 24.00 % （18/75） and 62.67 % （47/75） respectively. The expression of HER-2 and NF-KB were not correlated with age and gender, but with stage, grade and metastasis （P〈0.05）. The expression of NF-KB was correlated with tumor size （P〈0.05）, while HER-2 was not （P〈0.01）. When HER-2 was positive, NF-KB had a positive rate of 94.44 % （17/18）, but a positive rate of 52.63 % （30/57） when HER-2 was negative. Expression ofNF-KB in gastric cancer tissues was correlated with HER-2 expression （xZ=-8.514,P〈0.01）. Conclusions： The expression of NF-KB in gastric cancer tissues is correlated with HER-2 expression, and they may play a very important role in the progress of gastric cancer.